Dong Xiaokang, Li Yuqian, Zhang Lulu, Liu Xiaotian, Tu Runqi, Wang Yikang, Li Ruiying, Li Linlin, Hou Jian, Mao Zhenxing, Huo Wenqian, Wang Chongjian
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Arthritis Res Ther. 2021 Jan 6;23(1):7. doi: 10.1186/s13075-020-02385-8.
There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent and interactive association of PA and ST with HUA.
A cross-sectional analysis was performed on 38,855 participants (aged 18-79) enrolled from the Henan Rural Cohort Study at baseline (2015 to 2017). PA and ST levels were assessed by using the International Physical Activity Questionnaire (IPAQ). HUA was defined as a serum uric acid level of > 7.0 mg/dL for males and > 6.0 mg/dL for females. Multivariable logistic regression and linear regression models were applied to examine the independent association between PA or ST and HUA and serum uric acid level. Interaction plots were used to visualize the interaction effects of PA and ST on HUA.
PA level was inversely related with serum uric acid level (β - 0.15, 95% confidence interval (CI) - 0.22, - 0.07), but ST was positively related with uric acid level (β 2.12, 95% CI 1.90, 2.34). Metabolic equivalent (MET-hour/day) was associated with decreased prevalence of HUA (odds ratio (OR) 0.97, 95% CI 0.96, 0.99), while per hour increased for ST was associated with increased HUA (OR 1.05, 95% CI 1.04, 1.06). The interaction of PA and ST was significant (P < 0.001).
Exposure to higher ST was independently related to increased prevalence of HUA, while vigorous PA with a decreased HUA prevalence. Meanwhile, higher daily ST might attenuate the protective effect of PA on HUA.
The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699 ).
关于高尿酸血症（HUA）与中等至剧烈强度身体活动（PA）的研究较少，关于久坐时间（ST）的研究更是稀少。本研究的目的是探讨PA和ST与HUA之间的独立及交互关联。
对从河南农村队列研究基线期（2015年至2017年）纳入的38855名参与者（年龄18 - 79岁）进行横断面分析。使用国际体力活动问卷（IPAQ）评估PA和ST水平。HUA定义为男性血清尿酸水平>7.0mg/dL，女性>6.0mg/dL。应用多变量逻辑回归和线性回归模型来检验PA或ST与HUA及血清尿酸水平之间的独立关联。使用交互作用图来直观显示PA和ST对HUA的交互作用。
PA水平与血清尿酸水平呈负相关（β -0.15，95%置信区间（CI）-0.22，-0.07），但ST与尿酸水平呈正相关（β 2.12，95%CI 1.90，2.34）。代谢当量（MET -小时/天）与HUA患病率降低相关（比值比（OR）0.97，95%CI 0.96，0.99），而ST每增加1小时与HUA增加相关（OR 1.05，95%CI 1.04，1.06）。PA和ST的交互作用显著（P <0.001）。
长时间ST与HUA患病率增加独立相关，而剧烈PA与HUA患病率降低相关。同时，每日较长的ST可能会减弱PA对HUA的保护作用。
河南农村队列研究已在中国临床试验注册中心注册（注册号：ChiCTR - OOC - 15006699）
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