Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; Institute for Better Health, Trillium Health Partners, Mississauga, ON, Canada.
Res Social Adm Pharm. 2022 Sep;18(9):3501-3523. doi: 10.1016/j.sapharm.2022.03.003. Epub 2022 Mar 10.
Medication use is common for the prevention and treatment of many health conditions. Understanding the impact of medication-taking on quality of life is important, as it could contribute to better care plans and improve shared decision-making between patients and healthcare providers.
To systematically identify and summarize the extent of literature on patient-reported outcome measures (PROMs) for medication-related quality of life (QoL).
Medline, Embase, PsycINFO, and Health and Psychosocial Instruments databases were searched until May 17, 2021 for peer-reviewed, original research articles that included a PROM for medication-related QoL and reported its psychometric properties. Study selection were completed by pairs with a third reviewer resolving any conflicts. Data were extracted by the study team using a form in Microsoft Excel. Extracted data were summarized descriptively and tabulated numerically.
We screened 8,878 records, including 170 full-text articles, of which 86 met the criteria for inclusion. We identified 80 unique PROMs. Over half (n = 53) described measuring treatment satisfaction and less than one quarter measured medication related-QoL more broadly. Most of the included PROMs were targeted towards populations with specific health conditions including cancer (n = 9) and diabetes (n = 8), as well as individuals taking medication for non-specific conditions (n = 7). The most reported psychometric properties were internal consistency (n = 75) and construct validity (n = 77). All PROMs but one (n = 79) assessed physical health but fewer assessed other QoL dimensions (e.g., autonomy, interactions with providers).
We found that the PROMs were designed for condition-specific or medication-specific populations, with few for general medication-related QoL. Future research should focus on assessing medication-related QoL measures for broader populations such as those with disabilities, multimorbidity, or experiencing polypharmacy. There needs to be more guidance on how to implement the use of PROMs in clinical settings, as well as to ensure consistency around terminology related to QoL.
药物治疗在许多健康状况的预防和治疗中都很常见。了解药物治疗对生活质量的影响很重要，因为这有助于制定更好的护理计划，并促进患者和医疗保健提供者之间的共同决策。
系统地识别和总结与药物相关的生活质量（QoL）的患者报告结局测量（PROM）的文献范围。
直到 2021 年 5 月 17 日，我们在 Medline、Embase、PsycINFO 和 Health and Psychosocial Instruments 数据库中搜索了同行评议的原始研究文章，这些文章包括与药物相关的 QoL 的 PROM，并报告了其心理测量学特性。研究选择由两人完成，第三名评审员解决任何冲突。研究团队使用 Microsoft Excel 中的表格提取数据。提取的数据进行了描述性总结和数值制表。
我们筛选了 8878 条记录，包括 170 篇全文文章，其中 86 篇符合纳入标准。我们确定了 80 个独特的 PROM。超过一半（n=53）描述了治疗满意度的测量，不到四分之一的 PROM 更广泛地测量了与药物相关的 QoL。纳入的大多数 PROM 都针对特定健康状况的人群，包括癌症（n=9）和糖尿病（n=8），以及因非特定疾病而服用药物的个体（n=7）。报告最多的心理测量学特性是内部一致性（n=75）和结构有效性（n=77）。除了一个（n=79）外，所有的 PROM 都评估了身体健康，但评估其他 QoL 维度的较少（例如，自主性，与提供者的互动）。
我们发现 PROM 是为特定于疾病或特定于药物的人群设计的，很少有针对一般药物相关 QoL 的 PROM。未来的研究应集中在评估更广泛人群的药物相关 QoL 测量，例如残疾、多病共存或接受多药治疗的人群。需要更多关于如何在临床环境中实施 PROM 使用的指导，以及确保与 QoL 相关的术语一致性。
