将家族健康史扩展至纳入家族用药史。
Expanding Family Health History to Include Family Medication History.
作者信息
Haga Susanne B, Orlando Lori A
机构信息
Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.
出版信息
J Pers Med. 2023 Feb 25;13(3):410. doi: 10.3390/jpm13030410.
The collection of family health history (FHH) is an essential component of clinical practice and an important piece of data for patient risk assessment. However, family history data have generally been limited to diseases and have not included medication history. Family history was a key component of early pharmacogenetic research, confirming the role of genes in drug response. With the substantial number of known pharmacogenes, many affecting response to commonly prescribed medications, and the availability of clinical pharmacogenetic (PGx) tests and guidelines for interpretation, the collection of family medication history can inform testing decisions. This paper explores the roots of family-based pharmacogenetic studies to confirm the role of genes in these complex phenotypes and the benefits and challenges of collecting family medication history as part of family health history intake.
家族健康史（FHH）的收集是临床实践的重要组成部分，也是用于患者风险评估的重要数据。然而，家族史数据通常仅限于疾病，并未包括用药史。家族史是早期药物遗传学研究的关键组成部分，证实了基因在药物反应中的作用。鉴于已知大量药物基因，其中许多影响对常用处方药的反应，以及临床药物遗传学（PGx）检测和解读指南的可得性，收集家族用药史可为检测决策提供信息。本文探讨基于家族的药物遗传学研究的根源，以证实基因在这些复杂表型中的作用，以及将家族用药史作为家族健康史采集的一部分所带来的益处和挑战。
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