Dałek Paulina, Drabik Dominik, Wołczańska Halina, Foryś Aleksander, Jagas Małgorzata, Jędruchniewicz Natalia, Przybyło Magdalena, Witkiewicz Wojciech, Langner Marek
Laboratory for Biophysics of Macromolecular Aggregates, Department of Biomedical Engineering, Wrocław University of Science and Technology, Wrocław, Poland; Lipid Systems sp. z o.o., Wrocław, Poland.
Laboratory for Biophysics of Macromolecular Aggregates, Department of Biomedical Engineering, Wrocław University of Science and Technology, Wrocław, Poland.
Nanomedicine. 2022 Jul;43:102552. doi: 10.1016/j.nano.2022.102552. Epub 2022 Mar 26.
Vitamin D3 deficiency has serious health consequences, as demonstrated by its effect on severity and recovery after COVID-19 infection. Because of high hydrophobicity, its absorption and subsequent redistribution throughout the body are inherently dependent on the accompanying lipids and/or proteins. The effective oral vitamin D formulation should ensure penetration of the mucus layer followed by internalization by competent cells. Isothermal titration calorimetry and computer simulations show that vitamin D molecules cannot leave the hydrophobic environment, indicating that their absorption is predominantly driven by the digestion of the delivery vehicle. In the clinical experiment, liposomal vitamin D was compared to the oily formulation. The results obtained show that liposomal vitamin D causes a rapid increase in the plasma concentration of calcidiol. No such effect was observed when the oily formulation was used. The effect was especially pronounced for people with severe vitamin D deficiency.
维生素D3缺乏会产生严重的健康后果，这在其对新冠病毒感染后的严重程度和恢复情况的影响中得到了体现。由于其高度疏水性，它在体内的吸收及随后的重新分布本质上依赖于伴随的脂质和/或蛋白质。有效的口服维生素D制剂应确保穿透黏液层，随后被有能力的细胞内化。等温滴定量热法和计算机模拟表明维生素D分子无法离开疏水环境，这表明它们的吸收主要由递送载体的消化驱动。在临床实验中，将脂质体维生素D与油性制剂进行了比较。所得结果表明，脂质体维生素D会使骨化二醇的血浆浓度迅速升高。使用油性制剂时未观察到这种效果。对于严重维生素D缺乏的人，这种效果尤为明显。
