Kircher S, Schober E, Csepan R, Lubec G, Zehetner C, Marktl W, Klammer N, Gruska M
Padiatr Padol. 1986;21(3):265-8.
Using the cosinor system we examined the chronobiology of urinary beta-2-microglobulin excretion. The following dimensions were studied: urinary volume, creatinine concentration, creatinine excretion, beta-2-microglobulin concentration, beta-2-microglobulin excretion and the beta-2-microglobulin/creatinine ratio. Urinary volume showed an acrophase at 1704 hours (p = less than 0.01), creatinine concentration showed an acrophase at 0512 hrs (p = less than 0.006) and the beta-2-microglobulin/creatinine ratio presented an acrophase at 1736 hrs (p = less than 0.03). Data were related to a tau = 24 hrs. The data clearly reveal that the beta-2-microglobulin/creatinine ratio shows a circadian rhythm in urinary excretion.
我们使用余弦法研究了尿β2-微球蛋白排泄的时间生物学。研究了以下几个方面：尿量、肌酐浓度、肌酐排泄量、β2-微球蛋白浓度、β2-微球蛋白排泄量以及β2-微球蛋白/肌酐比值。尿量在1704时出现峰值（p<0.01），肌酐浓度在0512时出现峰值（p<0.006），β2-微球蛋白/肌酐比值在1736时出现峰值（p<0.03）。数据与24小时的周期相关。这些数据清楚地表明，β2-微球蛋白/肌酐比值在尿排泄中呈现昼夜节律。
