Howanietz H, Kircher S, Schober E, Marktl W, Klammer N, Gruska M, Lubec G
Padiatr Padol. 1987;22(1):13-7.
Acid glycosaminoglycans (AGAG, mucopolysaccharides) are major constituents of the extracellular matrix. They play a role in filtration and permeability processes, isolation and scaffolding. In childhood no circadian rhythms have been reported up to now. We examined 11 children testing the parameters of: urine volume, creatinine concentration and -excretion, glycosaminoglycan concentration and -excretion, the glycosaminoglycan/creatinine ratio, chondroitin 4 sulfate (Ch4S) in % of total AGAG, Ch4S in mg/2 hrs, heparan sulfate (HS) in % of total AGAG and HS in mg/2 hrs. The biorhythmicity of these data were processed by the cosinor system. We found significant circadian rhythmus for urine volume (acrophase at 1704 hrs, p = 0.05), creatinine concentration (acrophase at 0512 hrs, p = 0.01) and glycosaminoglycan concentration (acrophase at 0358 hrs, p = 0.005). The data presented can form the physiological basis for studies of biorhythmicity in several pathological states as e.g. diabetes and mucopolysaccaridoses.
酸性糖胺聚糖（AGAG，粘多糖）是细胞外基质的主要成分。它们在过滤和渗透过程、隔离和支架作用中发挥作用。到目前为止，尚未有关于儿童昼夜节律的报道。我们对11名儿童进行了检查，测试了以下参数：尿量、肌酐浓度和排泄量、糖胺聚糖浓度和排泄量、糖胺聚糖/肌酐比值、硫酸软骨素4（Ch4S）占总AGAG的百分比、每2小时Ch4S的毫克数、硫酸乙酰肝素（HS）占总AGAG的百分比以及每2小时HS的毫克数。这些数据的生物节律性通过余弦分析系统进行处理。我们发现尿量（高峰相位在1704时，p = 0.05）、肌酐浓度（高峰相位在0512时，p = 0.01）和糖胺聚糖浓度（高峰相位在0358时，p = 0.005）存在显著的昼夜节律。所呈现的数据可为研究几种病理状态（如糖尿病和粘多糖贮积症）的生物节律性提供生理基础。
