Rouhan D, Le Noc P, Le Noc D
Pathol Biol (Paris). 1986 May;34(5):404-9.
In vitro activity of ceftriaxone was studied on 245 cephalothin-resistant strains of enterobacteria representing 7 different phenotypes of resistance to cephalosporins and on 130 Gram negative oxidative bacilli. Ceftriaxone was compared to cefotaxime, cefmenoxime, moxalactam and ceftazidime. With modal MICs of 0.015 to 0.25 mg/l, ceftriaxone is active on all phenotypes of enterobacteria not simultaneously resistant to cefamandole and cefoxitin. Among the bacteria with this last phenotype, only K. pneumoniae, C. Freundii and E. cloacae are occasionally found to have intermediate susceptibility or even resistance; ceftriaxone is more active than cefotaxime, cefmenoxime and ceftazidime with inhibition of 95.1% of strains at 4 mg/l. Moxalactam is superior to ceftriaxone against enterobacteria that are intermediate or resistant to both cefamandole and cefoxitin. Activity of ceftazidime is strongest against oxidative bacilli and weakest against enterobacteria regardless of phenotype.
对245株对头孢菌素耐药的肠杆菌（代表7种不同的头孢菌素耐药表型）以及130株革兰氏阴性氧化杆菌进行了头孢曲松的体外活性研究。将头孢曲松与头孢噻肟、头孢甲肟、拉氧头孢和头孢他啶进行了比较。头孢曲松对所有不同时对头孢孟多和头孢西丁耐药的肠杆菌表型均有活性，其最低抑菌浓度（MIC）范围为0.015至0.25mg/l。在具有后一种表型的细菌中，仅偶尔发现肺炎克雷伯菌、弗氏柠檬酸杆菌和阴沟肠杆菌有中度敏感性甚至耐药性；头孢曲松比头孢噻肟、头孢甲肟和头孢他啶活性更强，在4mg/l时可抑制95.1%的菌株。对于对头孢孟多和头孢西丁均呈中度或耐药的肠杆菌，拉氧头孢优于头孢曲松。无论表型如何，头孢他啶对氧化杆菌的活性最强，对肠杆菌的活性最弱。
