Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2022 Mar 28;12(1):5235. doi: 10.1038/s41598-022-09221-w.
The purpose of this study was to elucidate the association between weight cycling and clinical outcomes such as type 2 diabetes and hypertension with differential effects of baseline age and obesity. Nationwide data from 6,132,569 healthy adults who underwent five or more health screenings between 2002 and 2011 were analyzed and followed until December 2019 for type 2 diabetes and hypertension. Weight cycling was defined as a change in body weight followed by another change in the opposite direction. Through the Cox proportional hazards model, the number and degree of weight cycles were positively associated with increased risk of type 2 diabetes and hypertension. The hazard ratios (HRs) of weight cycling for type 2 diabetes and hypertension were as high as 1.263 (1.213-1.315) and 1.175 (1.144-1.207) at two or more weight cycles of 10% of body weight (BW), respectively. The association was stronger for females, individuals with normal body weight/BMI, and older individuals. Weight cycling was significantly associated with an increased risk of adverse health outcomes and was stronger in individuals with normal BMI and females, indicating that these people should be informed about the potential risk of weight cycling.
本研究旨在阐明体重波动与 2 型糖尿病和高血压等临床结局之间的关联，并探讨基线年龄和肥胖的差异影响。分析了 2002 年至 2011 年期间接受过五次或更多次健康筛查的 6132569 名健康成年人的全国性数据，并随访至 2019 年 12 月，以观察 2 型糖尿病和高血压的发生情况。体重波动定义为体重先发生变化，然后向相反方向变化。通过 Cox 比例风险模型，体重波动的次数和幅度与 2 型糖尿病和高血压的风险增加呈正相关。体重波动 2 次或 2 次以上、体重波动幅度达到体重的 10%时，2 型糖尿病和高血压的风险比（HR）分别高达 1.263（1.213-1.315）和 1.175（1.144-1.207）。该关联在女性、体重正常/身体质量指数正常和年龄较大的个体中更强。体重波动与不良健康结局的风险增加显著相关，在体重正常的 BMI 和女性个体中更强，这表明应告知这些人体重波动的潜在风险。
