Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Xuhui District, Shanghai, China.
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
Sleep Breath. 2023 Mar;27(1):67-75. doi: 10.1007/s11325-022-02596-0. Epub 2022 Mar 28.
An earlier study found that heated humidification reduced the side effects of positive airway pressure (PAP) in patients with obstructive sleep apnoea (OSA). However, other studies disagreed with this finding. Therefore, we evaluated the relationship between heated humidification and the side effects of PAP in patients with OSA.
According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, six databases were searched for relevant randomised controlled trials (RCTs) performed from January 1999 to June 2021.
From 1012 retrieved articles, we identified 9 eligible RCTs. Compared to the control group, the heated humidification group reported improvements in dry nose (pooled standardised mean difference [SMD] = - 0.70, 95% confidence interval [CI] = - 0.96 to - 0.45, I = 0%, p < 0.00001), blocked nose (SMD = - 0.47, 95%CI - 0.69 to - 0.25, I = 36%, p < 0.0001), runny nose (SMD = - 0.22, 95%CI - 0.44 to 0, I = 0%, p = 0.05), dry mouth (SMD = - 0.62, 95%CI - 0.87 to - 0.37, I = 0%, p < 0.00001), and dry throat (SMD = - 0.61, 95%CI - 0.90 to - 0.33, I = 41%, p < 0.0001), but did not enhance positive airway pressure adherence (pooled mean difference [MD] = 0.24, 95% CI - 0.10 to 0.58, I = 0%, p = 0.17).
Heated humidification improved some PAP side effects in patients with OSA but did not increase PAP adherence. Additional large-scale multi-centre RCTs are needed to verify the long-term effects.
一项早期研究发现，加热湿化可减少阻塞性睡眠呼吸暂停（OSA）患者使用正压通气（PAP）的副作用。然而，其他研究并不认同这一发现。因此，我们评估了加热湿化与 OSA 患者 PAP 副作用之间的关系。
根据系统评价和荟萃分析的首选报告项目，从 1999 年 1 月至 2021 年 6 月，我们检索了六个数据库，以寻找相关的随机对照试验（RCT）。
从 1012 篇检索到的文章中，我们确定了 9 项符合条件的 RCT。与对照组相比，加热湿化组的鼻部干燥（合并标准化均数差 [SMD] = -0.70，95%置信区间 [CI] = -0.96 至 -0.45，I = 0%，p < 0.00001）、鼻塞（SMD = -0.47，95%CI = -0.69 至 -0.25，I = 36%，p < 0.0001）、流涕（SMD = -0.22，95%CI = -0.44 至 0，I = 0%，p = 0.05）、口干（SMD = -0.62，95%CI = -0.87 至 -0.37，I = 0%，p < 0.00001）和咽喉干燥（SMD = -0.61，95%CI = -0.90 至 -0.33，I = 41%，p < 0.0001）等 PAP 副作用得到改善，但并未提高 PAP 依从性（合并平均差 [MD] = 0.24，95%CI = -0.10 至 0.58，I = 0%，p = 0.17）。
加热湿化可改善 OSA 患者的部分 PAP 副作用，但不会增加 PAP 依从性。需要开展更多的大型多中心 RCT 来验证其长期效果。
