Department of Neurology, National Medical Center, Seoul, Korea.
J Korean Med Sci. 2022 Mar 28;37(12):e97. doi: 10.3346/jkms.2022.37.e97.
Seizure is an uncommon complication of coronavirus disease 2019 (COVID-19). The frequency and characteristics of new-onset seizures in hospitalized patients with COVID-19 were investigated. Of a total of 1,487 patients with confirmed COVID-19, six (0.4%) developed new-onset seizures. All six had severe or critical COVID-19 requiring intensive care and mechanical ventilation or high-flow oxygen therapy. Among COVID-19 patients admitted to the intensive care unit (n = 169), the incidence of new-onset seizures was 3.6%. Underlying structural lesions (acute infarction and remote hemorrhage), hypoxia, sepsis, and metabolic derangements were associated with the development of seizures. Of the six patients, three patients died, and, at the time of discharge, one patient had a severe disability, while the remaining two were well recovered.
癫痫发作是 2019 冠状病毒病（COVID-19）少见的并发症。研究了住院 COVID-19 患者新发癫痫发作的频率和特征。在总共 1487 例确诊 COVID-19 患者中，有 6 例（0.4%）出现新发癫痫发作。这 6 例患者均患有严重或危重症 COVID-19，需要重症监护和机械通气或高流量吸氧治疗。在入住重症监护病房（n = 169）的 COVID-19 患者中，新发癫痫发作的发生率为 3.6%。癫痫发作的发生与结构性病变（急性梗死和陈旧性出血）、缺氧、脓毒症和代谢紊乱有关。这 6 例患者中，有 3 例死亡，出院时 1 例患者有严重残疾，其余 2 例患者恢复良好。
