Department of Radiology and Biomedical Imaging University of CaliforniaSan Francisco, and San Francisco Veterans Affairs Medical Center San Francisco CA.
San Francisco Veterans Affairs Medical Center San Francisco CA.
J Am Heart Assoc. 2022 Apr 5;11(7):e024571. doi: 10.1161/JAHA.121.024571. Epub 2022 Mar 29.
Background Abdominal aortic aneurysm (AAA) screening programs have been active in the United States since 2005, but are not the only way AAAs are detected. AAA management and outcomes have not been investigated broadly in the context of "implicit AAA screening," whereby radiologic examinations not intended for focused screening can identify AAAs. Methods and Results We examined the association between imaging-based AAA screening, both explicit and implicit, and various outcomes for ≈1.6 million veterans in the Veterans Affairs health care system from 2005 to 2015. Screened-positive, screened-negative, and unscreened veterans were identified in the overall cohort and within a subgroup of veterans aged 65 years in 2005. The yearly composite screening rate increased over 10 years, from 11.7% to 18.3%, whereas the screened-positive rate decreased from 7.3% to 4.9%. Only 12.9% of screening examinations were explicit AAA screening ultrasounds. The subgroup's composite screening rate was 74% within its 10-year eligibility window, with implicit screening accounting for 91.8% of examinations. In the 2005 subgroup, all-cause mortality and Charlson comorbidity scores were higher for veterans who underwent screening compared with those unscreened (31.2% versus 23.1% and 0.47 versus 0.25, respectively; <0.001). AAA rupture rates were similar between those unscreened and screened-negative individuals. Conclusions Accounting for both explicit and implicit screening, AAA screening in the Veterans Affairs population has moderate reach. Efforts to expand explicit AAA screening are not likely to impact either all-cause mortality or AAA rupture on the population scale as significantly as a careful accounting for and use of implicit screening data.
背景 自 2005 年以来,美国一直在开展腹主动脉瘤(AAA)筛查项目,但这并不是发现 AAA 的唯一途径。在“隐性 AAA 筛查”背景下,尚未广泛研究 AAA 的管理和结局,即并非专门用于筛查的影像学检查也可发现 AAA。
方法和结果 我们研究了 2005 年至 2015 年期间,退伍军人事务部医疗保健系统中约 160 万退伍军人的基于影像学的显性和隐性 AAA 筛查与各种结局之间的关系。在整个队列和 2005 年年龄在 65 岁及以上的退伍军人亚组中,我们确定了筛查阳性、筛查阴性和未筛查退伍军人。经过 10 年,每年的综合筛查率从 11.7%增加到 18.3%,而筛查阳性率从 7.3%降至 4.9%。只有 12.9%的筛查检查是显性 AAA 筛查超声。该亚组在 10 年的资格期内综合筛查率为 74%,其中隐性筛查占检查的 91.8%。在 2005 年亚组中,与未筛查者相比,接受筛查的退伍军人的全因死亡率和 Charlson 合并症评分更高(分别为 31.2%和 23.1%,0.47 和 0.25;<0.001)。未筛查者和筛查阴性者的 AAA 破裂率相似。
结论 考虑到显性和隐性筛查,退伍军人事务部人群中的 AAA 筛查具有中等范围。在人群层面上,扩大显性 AAA 筛查的努力不太可能像认真考虑和使用隐性筛查数据那样,对全因死亡率或 AAA 破裂产生重大影响。