Division of Gastroenterology, Department of Paediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Division of Ambulatory Paediatrics and Adolescent Medicine, Department of Paediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Paediatr Child Health. 2022 Jul;58(7):1209-1214. doi: 10.1111/jpc.15950. Epub 2022 Mar 29.
Functional abdominal pain disorders (FAPDs) and functional constipation (FC) are the common functional gastrointestinal disorders in adolescents. We aimed to determine the prevalence of FAPDs and FC in adolescents using the Rome IV Questionnaire of Pediatric Gastrointestinal Symptoms and the factors associated with these two functional gastrointestinal disorders.
A survey for the prevalence of FAPDs and FC in adolescents was carried out at two high schools. A translated and validated Thai version of Rome IV Questionnaire of Pediatric Gastrointestinal Symptoms was used. Potential associated factors were also collected. Psychosocial problems were evaluated by using the Strengths and Difficulties Questionnaire.
A total of 1700 adolescents (55.5% females) with a mean age (SD) of 16.1 (0.9) years were enrolled. The prevalence of FAPDs and FC was 5.3% and 8.1%, respectively. The subtypes of FAPDs were functional dyspepsia (4.7%; postprandial distress syndrome 3.9% and epigastric pain syndrome 0.8%), irritable bowel syndrome (0.6%), abdominal migraine (0.4%) and functional abdominal pain not otherwise specified (0.3%). Multiple logistic regression analysis revealed that FAPDs were associated with female gender (odds ratio (OR) 3.3, 95% confidence interval (CI): 1.7-6.4), underlying allergic diseases (OR 3.2, 95% CI: 1.6-6.6) and concomitant emotional problem (OR 2.7, 95% CI: 1.2-5.9). No significant associated factors with FC were found.
FAPDs and FC are common in adolescents. Postprandial distress syndrome is the most common subtype of FAPD. Associated factors for FAPDs may suggest hormonal, immune-related and psychological involvement in the disease pathogenesis.
功能性腹痛障碍（FAPDs）和功能性便秘（FC）是青少年常见的功能性胃肠道疾病。本研究旨在使用罗马 IV 儿童胃肠道症状问卷评估青少年 FAPDs 和 FC 的患病率，并确定与这两种功能性胃肠道疾病相关的因素。
在两所高中开展青少年 FAPDs 和 FC 患病率调查。使用经翻译和验证的罗马 IV 儿童胃肠道症状问卷进行调查。还收集了潜在的相关因素。使用长处和困难问卷评估心理社会问题。
共纳入 1700 名青少年（55.5%为女性），平均年龄（标准差）为 16.1（0.9）岁。FAPDs 和 FC 的患病率分别为 5.3%和 8.1%。FAPDs 的亚型为功能性消化不良（4.7%；餐后不适综合征 3.9%和上腹疼痛综合征 0.8%）、肠易激综合征（0.6%）、腹型偏头痛（0.4%）和功能性腹痛未特指型（0.3%）。多因素 logistic 回归分析显示，FAPDs 与女性（比值比（OR）3.3，95%置信区间（CI）：1.7-6.4）、潜在过敏性疾病（OR 3.2，95% CI：1.6-6.6）和伴发情绪问题（OR 2.7，95% CI：1.2-5.9）相关。未发现 FC 的相关显著因素。
FAPDs 和 FC 在青少年中较为常见。餐后不适综合征是 FAPD 最常见的亚型。FAPDs 的相关因素可能提示疾病发病机制涉及激素、免疫相关和心理因素。
