Niutta E, Tripodi M G, Cusi D, Pati C, Dossi F, Elli A, Bianchi G
Postgrad Med J. 1986;62 Suppl 1:13-5.
We measured red blood cell Na+-K+ pump, Na+-Li+ countertransport and Na+-K+ cotransport activities, together with intraerythrocyte sodium content before and after 3 months therapy with captopril and two other antihypertensive drugs (atenolol and canrenoate potassium) in subjects suffering from essential hypertension. All patients discontinued any previous treatment at least 3 months before the basal evaluation of cell membrane activities. All three drugs significantly lowered blood pressure but only captopril and canrenoate potassium induced significant modifications in red blood cell parameters. After three months of captopril therapy intraerythrocyte Na+ content was significantly decreased (P less than 0.01) without any detectable change in cation transport system activity. After 3 months of canrenoate potassium therapy we also observed a significant decrease in internal Na content (P less than 0.01), together with a significant increase in Na+-K+ pump (P less than 0.02) and Na+-Li+ countertransport (P less than 0.05) activities.
我们对原发性高血压患者在使用卡托普利及其他两种抗高血压药物（阿替洛尔和坎利酸钾）治疗3个月前后的红细胞钠钾泵、钠锂逆向转运及钠钾协同转运活性，以及红细胞内钠含量进行了测定。所有患者在进行细胞膜活性基础评估前至少3个月停用之前的任何治疗。所有三种药物均显著降低了血压，但只有卡托普利和坎利酸钾引起了红细胞参数的显著改变。卡托普利治疗3个月后，红细胞内钠含量显著降低（P<0.01），而阳离子转运系统活性无任何可检测到的变化。坎利酸钾治疗3个月后，我们还观察到细胞内钠含量显著降低（P<0.01），同时钠钾泵活性（P<0.02）和钠锂逆向转运活性（P<0.05）显著增加。
