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1
Lowering the risk of autism spectrum disorder with folic acid: can there be too much of a good thing?叶酸能否降低自闭症谱系障碍的风险：好事会过头吗？
Am J Clin Nutr. 2022 May 1;115(5):1268-1269. doi: 10.1093/ajcn/nqac048.
2
Plasma unmetabolized folic acid in pregnancy and risk of autistic traits and language impairment in antiseizure medication-exposed children of women with epilepsy.孕妇血浆中未代谢的叶酸与癫痫女性所生抗癫痫药物暴露儿童自闭症特征和语言障碍风险的关系。
Am J Clin Nutr. 2022 May 1;115(5):1432-1440. doi: 10.1093/ajcn/nqab436.
3
Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders.孕前及孕期补充叶酸和多种维生素的摄入与自闭症谱系障碍
Autism. 2016 Aug;20(6):710-8. doi: 10.1177/1362361315604076. Epub 2015 Sep 25.
4
Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development.研究综述和荟萃分析发现，产前叶酸与自闭症风险降低 58%有关，但对智力和运动发育没有影响。
Acta Paediatr. 2019 Apr;108(4):600-610. doi: 10.1111/apa.14657. Epub 2018 Dec 12.
5
Folic acid and autism: What do we know?叶酸与自闭症：我们了解什么？
Nutr Neurosci. 2016 Sep;19(7):310-7. doi: 10.1179/1476830514Y.0000000142. Epub 2016 Mar 1.
6
Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero.妊娠期间补充叶酸与暴露于抗癫痫药物的儿童自闭症风险的关联。
JAMA Neurol. 2018 Feb 1;75(2):160-168. doi: 10.1001/jamaneurol.2017.3897.
7
Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children.母亲使用叶酸补充剂与儿童自闭症谱系障碍风险的关联。
JAMA. 2013 Feb 13;309(6):570-7. doi: 10.1001/jama.2012.155925.
8
Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring.母亲在怀孕前和怀孕期间使用叶酸和多种维生素补充剂与后代自闭症谱系障碍风险的关联。
JAMA Psychiatry. 2018 Feb 1;75(2):176-184. doi: 10.1001/jamapsychiatry.2017.4050.
9
Association of maternal prenatal folic acid intake with subsequent risk of autism spectrum disorder in children: A systematic review and meta-analysis.母亲产前叶酸摄入与儿童自闭症谱系障碍风险的关联：系统评价和荟萃分析。
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109650. doi: 10.1016/j.pnpbp.2019.109650. Epub 2019 May 11.
10
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.产前丙戊酸盐暴露与自闭症谱系障碍和儿童自闭症的风险。
JAMA. 2013 Apr 24;309(16):1696-703. doi: 10.1001/jama.2013.2270.

引用本文的文献

1
Human milk unmetabolized folic acid is increased following supplementation with synthetic folic acid as compared to (6S)-5-methyltetrahydrofolic acid.与（6S）-5-甲基四氢叶酸相比，补充合成叶酸会增加人乳中未代谢的叶酸。
Sci Rep. 2023 Jul 12;13(1):11298. doi: 10.1038/s41598-023-38224-4.
2
Autistic spectrum disorder (ASD) - Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopment.自闭症谱系障碍（ASD）——连接全身炎症、线粒体功能障碍、跨突触信号传导和神经发育的基因、分子及通路特征
Brain Behav Immun Health. 2023 Jun 5;30:100646. doi: 10.1016/j.bbih.2023.100646. eCollection 2023 Jul.

本文引用的文献

1
Plasma unmetabolized folic acid in pregnancy and risk of autistic traits and language impairment in antiseizure medication-exposed children of women with epilepsy.孕妇血浆中未代谢的叶酸与癫痫女性所生抗癫痫药物暴露儿童自闭症特征和语言障碍风险的关系。
Am J Clin Nutr. 2022 May 1;115(5):1432-1440. doi: 10.1093/ajcn/nqab436.
2
Expression Changes in Epigenetic Gene Pathways Associated With One-Carbon Nutritional Metabolites in Maternal Blood From Pregnancies Resulting in Autism and Non-Typical Neurodevelopment.与自闭症和非典型神经发育相关的母婴血液中单碳营养代谢物相关的表观遗传基因途径的表达变化。
Autism Res. 2021 Jan;14(1):11-28. doi: 10.1002/aur.2428. Epub 2020 Nov 7.
3
Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.理解过量叶酸/叶酸的代谢和临床影响方面的知识差距：NIH 研讨会的总结和观点。
Am J Clin Nutr. 2020 Nov 11;112(5):1390-1403. doi: 10.1093/ajcn/nqaa259.
4
A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder.脐带血叶酸亚型与自闭症谱系障碍风险的前瞻性出生队列研究。
Am J Clin Nutr. 2020 Nov 11;112(5):1304-1317. doi: 10.1093/ajcn/nqaa208.
5
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016.2016 年，美国 11 个监测点自闭症和发育障碍监测网络对 8 岁儿童自闭症谱系障碍流行率的调查。
MMWR Surveill Summ. 2020 Mar 27;69(4):1-12. doi: 10.15585/mmwr.ss6904a1.
6
Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort.五国队列中遗传和环境因素与自闭症的关联
JAMA Psychiatry. 2019 Oct 1;76(10):1035-1043. doi: 10.1001/jamapsychiatry.2019.1411.
7
Maternal Multivitamin Intake, Plasma Folate and Vitamin B Levels and Autism Spectrum Disorder Risk in Offspring.孕期多种维生素摄入、母体血浆叶酸和维生素B水平与子代患自闭症谱系障碍的风险
Paediatr Perinat Epidemiol. 2018 Jan;32(1):100-111. doi: 10.1111/ppe.12414. Epub 2017 Oct 6.
8
Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.孕期高剂量叶酸补充剂对4-5岁儿童神经认知发育的影响：前瞻性出生队列研究“Infancia y Medio Ambiente（INMA）”
Am J Clin Nutr. 2017 Sep;106(3):878-887. doi: 10.3945/ajcn.117.152769. Epub 2017 Jul 19.
9
New Perspective on Impact of Folic Acid Supplementation during Pregnancy on Neurodevelopment/Autism in the Offspring Children - A Systematic Review.孕期补充叶酸对后代儿童神经发育/自闭症影响的新视角——一项系统综述
PLoS One. 2016 Nov 22;11(11):e0165626. doi: 10.1371/journal.pone.0165626. eCollection 2016.
10
Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children.母亲使用叶酸补充剂与儿童自闭症谱系障碍风险的关联。
JAMA. 2013 Feb 13;309(6):570-7. doi: 10.1001/jama.2012.155925.

Lowering the risk of autism spectrum disorder with folic acid: can there be too much of a good thing?

作者信息

Mills James L, Molloy Anne M

机构信息

Epidemiology Branch, Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.

Department of Clinical Medicine, School of Medicine, Trinity College, Dublin, Ireland.

出版信息

Am J Clin Nutr. 2022 May 1;115(5):1268-1269. doi: 10.1093/ajcn/nqac048.

DOI:10.1093/ajcn/nqac048
PMID:35348591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9071475/
Abstract
摘要