Libretti A, Catalano M
Postgrad Med J. 1986;62 Suppl 1:34-7.
The effect of captopril was studied in 40 hypertensive patients (WHO stages I and II) with peripheral vascular disease of the lower limbs (Fontaine stages IIa and IIb). We assessed systolic and diastolic arterial pressure, heart rate in supine and upright position, relative and absolute pain free intervals, and ankle/arm pressure index at rest and after treadmill exercise test. In the first part of the study 20 patients were divided into two groups, one of which was treated with chlorthalidone (25 mg/day) and the other with captopril (50 mg two times a day) for 8 weeks. Statistically significant improvements were only obtained in the captopril-treated group. They concerned the ankle/arm pressure index at rest (P less than 0.05) and after exercise (P less than 0.05) and the absolute pain free interval (P less than 0.05) as well as systolic arterial pressure. Furthermore, 20 more patients were treated with captopril (50 mg two times a day) for 8 weeks, and improvements were found in ankle/arm pressure index at rest (P less than 0.01) and after exercise (P less than 0.001) and in relative and absolute pain free intervals (P less than 0.001) as well as in systolic and diastolic arterial pressure. These results indicate an increase in flow to the limbs of patients with vascular disease treated with captopril, and suggest that captopril is an effective drug without contraindications for the treatment of hypertension associated with claudication.
对40例患有下肢外周血管疾病（Fontaine IIa和IIb期）的高血压患者（WHO I期和II期）进行了卡托普利疗效的研究。我们评估了收缩压和舒张压、仰卧位和直立位心率、相对和绝对无痛间隔以及静息和运动平板试验后的踝/臂压力指数。在研究的第一部分，20例患者被分为两组，其中一组接受氯噻酮（25毫克/天）治疗，另一组接受卡托普利（50毫克，每日两次）治疗，为期8周。仅在卡托普利治疗组中获得了具有统计学意义的改善。这些改善涉及静息时（P<0.05）和运动后（P<0.05）的踝/臂压力指数、绝对无痛间隔（P<0.05）以及收缩压。此外，另外20例患者接受卡托普利（50毫克，每日两次）治疗8周，发现静息时（P<0.01）和运动后（P<0.001）的踝/臂压力指数、相对和绝对无痛间隔（P<0.001）以及收缩压和舒张压均有改善。这些结果表明，用卡托普利治疗的血管疾病患者肢体血流量增加，提示卡托普利是一种治疗与间歇性跛行相关高血压且无禁忌证的有效药物。
