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卡托普利对冠状动脉供血不足患者心肌灌注的影响:通过运动试验及使用铊-201的定量心肌断层闪烁显像法进行评估

Effects of captopril on myocardial perfusion in patients with coronary insufficiency: evaluation by the exercise test and quantitative myocardial tomoscintigraphy using thallium-201.

作者信息

Tardieu A, Virot P, Vandroux J C, Vergnoux H, Pinaud D, Chabanier A, Bensaid J

出版信息

Postgrad Med J. 1986;62 Suppl 1:38-41.

PMID:3534863
Abstract

Nine patients with coronary insufficiency were investigated using an exercise test coupled with quantitative myocardial tomoscintigraphy with thallium-201 before and after 48 hours' treatment with captopril. After captopril treatment, an improvement in ST segment depression was noted during exercise. The quantitative tomoscintigraphy showed a reduction in the ischaemic zone with captopril during exercise. However, in three patients, although there was an overall improvement in myocardial perfusion during exercise, aggravation of wash-out was observed in some regions, reminiscent of a coronary steal effect.

摘要

对9例冠状动脉供血不足患者在使用卡托普利治疗48小时前后,进行了运动试验结合定量心肌铊-201断层闪烁扫描检查。卡托普利治疗后,运动期间ST段压低情况有所改善。定量断层闪烁扫描显示,运动时使用卡托普利使缺血区缩小。然而,有3例患者,尽管运动期间心肌灌注总体有所改善,但在某些区域观察到洗脱加剧,这让人联想到冠状动脉窃血效应。

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Effects of captopril on myocardial perfusion in patients with coronary insufficiency: evaluation by the exercise test and quantitative myocardial tomoscintigraphy using thallium-201.卡托普利对冠状动脉供血不足患者心肌灌注的影响:通过运动试验及使用铊-201的定量心肌断层闪烁显像法进行评估
Postgrad Med J. 1986;62 Suppl 1:38-41.
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The variable effects of angiotensin converting enzyme inhibition on myocardial ischaemia in chronic stable angina.血管紧张素转换酶抑制对慢性稳定型心绞痛心肌缺血的可变效应。
Br Heart J. 1989 Aug;62(2):112-7. doi: 10.1136/hrt.62.2.112.
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ACE inhibitors for the treatment of myocardial ischemia?用于治疗心肌缺血的血管紧张素转换酶抑制剂?
Cardiovasc Drugs Ther. 1990 Oct;4(5):1375-84. doi: 10.1007/BF02018265.
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Current concepts: converting enzyme inhibitors in coronary artery disease.当前概念:冠状动脉疾病中的转换酶抑制剂
Clin Investig. 1992 Jan;70(1):70-6. doi: 10.1007/BF00422945.