新型冠状病毒肺炎（COVID-19）对公共卫生的影响，以及针对遗传易感性和疾病严重程度的假设驱动型研究。
COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity.
机构信息
Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA,IP), Lisboa, Portugal.
Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
出版信息
Immunogenetics. 2022 Aug;74(4):381-407. doi: 10.1007/s00251-022-01261-w. Epub 2022 Mar 29.
COVID-19 is a new complex multisystem disease caused by the novel coronavirus SARS-CoV-2. In slightly over 2 years, it infected nearly 500 million and killed 6 million human beings worldwide, causing an unprecedented coronavirus pandemic. Currently, the international scientific community is engaged in elucidating the molecular mechanisms of the pathophysiology of SARS-CoV-2 infection as a basis of scientific developments for the future control of COVID-19. Global exome and genome analysis efforts work to define the human genetics of protective immunity to SARS-CoV-2 infection. Here, we review the current knowledge regarding the SARS-CoV-2 infection, the implications of COVID-19 to Public Health and discuss genotype to phenotype association approaches that could be exploited through the selection of candidate genes to identify the genetic determinants of severe COVID-19.
COVID-19 是一种由新型冠状病毒 SARS-CoV-2 引起的新的复杂多系统疾病。在短短两年多的时间里，它感染了近 5 亿人，导致全球 600 万人死亡，引发了一场前所未有的冠状病毒大流行。目前，国际科学界正在阐明 SARS-CoV-2 感染的病理生理学分子机制，作为未来控制 COVID-19 的科学发展的基础。全球外显子组和基因组分析工作旨在确定对 SARS-CoV-2 感染具有保护免疫力的人类遗传学。在这里，我们回顾了目前关于 SARS-CoV-2 感染的知识，讨论了 COVID-19 对公共卫生的影响，并讨论了基因型到表型关联的方法，这些方法可以通过选择候选基因来识别严重 COVID-19 的遗传决定因素来利用。
Zotero 插件