West Haven Pharmacy, West Haven, CT, 06516, USA.
The Ohio State University Wexner Medical Center, James Cancer Hospital, Columbus, OH, USA.
Inflammopharmacology. 2022 Jun;30(3):713-723. doi: 10.1007/s10787-022-00963-7. Epub 2022 Mar 28.
Neuropathic pain (NP) is a chronic condition that affects ~ 1% of the general population globally. Several conditions such as chronic diabetes, herpes zoster (HZ), cancer, HIV, stroke, multiple sclerosis, physical compression or damage of nerves and certain surgical procedures can lead to neuropathy and related pain. The condition is difficult to treat with traditional analgesic drugs. Typically, non-traditional analgesics are used in treating pain in this condition such as antidepressants and antiepileptic drugs. Opioids are useful in some patients, but the risk of addiction and the risk of both short-term and long-term adverse effects make it a low priority drug class in the treatment of NP. In the current review we discuss the pharmacology and pharmaceutical care aspects of various classes of drugs used in the treatment of NP, counselling points for these drug classes, and future prospects in the treatment of NP.
神经性疼痛（NP）是一种慢性疾病，影响全球约 1%的普通人群。几种情况，如慢性糖尿病、带状疱疹（HZ）、癌症、HIV、中风、多发性硬化症、神经的物理压迫或损伤以及某些手术程序，都可能导致神经病变和相关疼痛。这种情况用传统的镇痛药很难治疗。通常，非传统的镇痛药用于治疗这种情况下的疼痛，如抗抑郁药和抗癫痫药。阿片类药物对一些患者有用，但成瘾风险以及短期和长期不良反应的风险使得它们在治疗 NP 中的优先级较低。在本次综述中，我们讨论了用于治疗 NP 的各类药物的药理学和药物治疗方面、这些药物类别的咨询要点，以及 NP 治疗的未来前景。
