A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center Kazan Scientific Center, Russian Academy of Sciences, Kazan, Republic of Tatarstan, Russia.
Kazan Institute of Biochemistry and Biophysics, Federal Research Center Kazan Scientific Center, Russian Academy of Sciences, Kazan, Republic of Tatarstan, Russia.
Bull Exp Biol Med. 2022 Mar;172(5):534-538. doi: 10.1007/s10517-022-05427-0. Epub 2022 Mar 29.
The role of α7 nicotinic acetylcholine receptors in coupling of synaptic activity and muscle contractions was studied in frog (Rana ridibunda) neuromuscular synapses. The amplitude of endplate currents, the probability of action potential generation, and the strength of muscle contractions decreased in the presence of selective α7 antagonist methyllycaconitine. The effects of nicotinic acetylcholine receptor blockade depended on the pattern of the motor nerve stimulation. It can be assumed that the muscle action potential is a factor of retrograde control of neurosecretion, which modulates activity of α7 nicotinic receptors and the release of acetylcholine from motor nerve endings.
α7 型烟碱型乙酰胆碱受体在突触活动和肌肉收缩偶联中的作用在青蛙（Rana ridibunda）的神经肌肉突触中进行了研究。在选择性 α7 拮抗剂甲基戊二酰胆碱存在的情况下，终板电流幅度、动作电位发生的概率和肌肉收缩的强度降低。烟碱型乙酰胆碱受体阻断的作用取决于运动神经刺激的模式。可以假设肌肉动作电位是神经分泌逆行控制的一个因素，它调节α7 型烟碱受体的活性和运动神经末梢乙酰胆碱的释放。
