Centre for Neuroendocrinology and Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
Trends Neurosci. 2013 Aug;36(8):471-9. doi: 10.1016/j.tins.2013.04.007. Epub 2013 May 21.
Retrograde signaling is a fundamental means by which neurons communicate. The acceptance of this statement has required a revision of how we view transmission and storage of information at the synapse. Although there is a substantial body of literature on the diverse molecules that serve as retrograde signals, less is known about how retrograde signal capacity can be modified. Is retrograde signaling plastic? How does this plasticity manifest? Are there behavioral correlates that may bias a neuron towards 'changing its tune', retrogradely speaking, of course? Here, we review recent findings that retrograde signaling is a highly labile process that adds additional layers of complexity that must be untangled to understand information processing in the nervous system.
逆行信号是神经元通讯的基本方式。这一观点的接受要求我们对突触处信息传递和存储的方式进行修正。尽管有大量关于逆行信号分子多样性的文献，但对于如何改变逆行信号的容量知之甚少。逆行信号是可塑的吗？这种可塑性表现在哪里？是否存在行为相关性，使神经元倾向于“改变曲调”，当然是逆行地改变？在这里，我们回顾了最近的发现，即逆行信号是一个高度易变的过程，增加了更多的复杂性，必须加以梳理，才能理解神经系统中的信息处理。
