Chemical biology-based approaches to study adenosine A - dopamine D receptor heteromers.
作者信息
Gregory Karen J, Jörg Manuela
机构信息
Drug Discovery Biology Theme, ARC Centre for Cryo-Electron Microscopy of Membrane Proteins and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia.
Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia.
出版信息
Purinergic Signal. 2022 Dec;18(4):395-398. doi: 10.1007/s11302-022-09860-8. Epub 2022 Mar 29.
Abstract
摘要
相似文献
1
Chemical biology-based approaches to study adenosine A - dopamine D receptor heteromers.基于化学生物学的方法研究腺苷A-多巴胺D受体异聚体。
Purinergic Signal. 2022 Dec;18(4):395-398. doi: 10.1007/s11302-022-09860-8. Epub 2022 Mar 29.
2
Behavioral control by striatal adenosine A -dopamine D receptor heteromers.纹状体腺苷A-多巴胺D受体异聚体对行为的控制
Genes Brain Behav. 2018 Apr;17(4):e12432. doi: 10.1111/gbb.12432. Epub 2017 Nov 17.
3
Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes.控制纹状体星形细胞上的高级受体复合物中的多巴胺信号。
Int J Mol Sci. 2024 Aug 7;25(16):8610. doi: 10.3390/ijms25168610.
4
A2A-D2 Heteromers on Striatal Astrocytes: Biochemical and Biophysical Evidence.A2A-D2 异源二聚体在纹状体星形细胞上：生化和生物物理证据。
Int J Mol Sci. 2019 May 17;20(10):2457. doi: 10.3390/ijms20102457.
5
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer.腺苷A2A受体 - 多巴胺D2受体异四聚体内激动剂与拮抗剂之间的变构相互作用。
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3609-18. doi: 10.1073/pnas.1507704112. Epub 2015 Jun 22.
6
Increased sensitivity in the interaction of the dopaminergic/adenosinergic system at the level of the adenylate cyclase activity in the striatum of the "weaver" mouse.在“编织者”小鼠纹状体中，多巴胺能/腺苷能系统在腺苷酸环化酶活性水平上的相互作用敏感性增加。
Neurochem Int. 2016 Oct;99:233-238. doi: 10.1016/j.neuint.2016.08.002. Epub 2016 Aug 4.
7
Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers.腺苷A2A受体拮抗剂/多巴胺D2受体激动剂二价配体作为检测A2A-D2受体异聚体的药理学工具。
J Med Chem. 2009 Sep 24;52(18):5590-602. doi: 10.1021/jm900298c.
8
Adenosine A receptors modulate the dopamine D receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex.腺苷 A 受体调节小鼠前额叶皮层中多巴胺 D 受体介导的突触传递抑制。
Eur J Neurosci. 2018 May;47(9):1127-1134. doi: 10.1111/ejn.13912. Epub 2018 Apr 2.
9
Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders.腺苷A2A-多巴胺D2受体异聚体。神经精神疾病的靶点。
Parkinsonism Relat Disord. 2004 Jul;10(5):265-71. doi: 10.1016/j.parkreldis.2004.02.014.
10
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.A2A 腺苷受体与 D2 多巴胺受体的相互作用调节皮质纹状体谷氨酸能传递。
Neuropharmacology. 2007 Nov;53(6):783-9. doi: 10.1016/j.neuropharm.2007.08.006. Epub 2007 Aug 16.
引用本文的文献
1
Ligand-directed covalent labelling of adenosine receptors.腺苷受体的配体导向共价标记
Purinergic Signal. 2025 Feb 24. doi: 10.1007/s11302-025-10073-y.
本文引用的文献
1
Heterobivalent Ligand for the Adenosine A-Dopamine D Receptor Heteromer.双价配体与腺苷 A-多巴胺 D 受体异源二聚体。
J Med Chem. 2022 Jan 13;65(1):616-632. doi: 10.1021/acs.jmedchem.1c01763. Epub 2022 Jan 4.
2
Design of bivalent ligands targeting putative GPCR dimers.双价配体设计针对假定的 G 蛋白偶联受体二聚体。
Drug Discov Today. 2021 Jan;26(1):189-199. doi: 10.1016/j.drudis.2020.10.006. Epub 2020 Oct 16.
3
Decreased striatal adenosine A-dopamine D receptor heteromerization in schizophrenia.精神分裂症中纹状体腺苷A-多巴胺D受体异聚体减少。
Neuropsychopharmacology. 2021 Feb;46(3):665-672. doi: 10.1038/s41386-020-00872-9. Epub 2020 Oct 3.
4
Revealing Adenosine A-Dopamine D Receptor Heteromers in Parkinson's Disease Post-Mortem Brain through a New AlphaScreen-Based Assay.通过一种新的基于 AlphaScreen 的检测方法揭示帕金森病尸检大脑中的腺苷 A-多巴胺 D 受体异源二聚体。
Int J Mol Sci. 2019 Jul 23;20(14):3600. doi: 10.3390/ijms20143600.
5
Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment.基底神经节中的腺苷异源受体复合物与帕金森病及其治疗有关。
J Neural Transm (Vienna). 2019 Apr;126(4):455-471. doi: 10.1007/s00702-019-01969-2. Epub 2019 Jan 14.
6
Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer.设计一种具有皮摩尔亲和力的真正二价配体，用于与 G 蛋白偶联受体同源二聚体结合。
J Med Chem. 2018 Oct 25;61(20):9335-9346. doi: 10.1021/acs.jmedchem.8b01249. Epub 2018 Oct 11.
7
The size matters? A computational tool to design bivalent ligands.大小很重要？设计双价配体的计算工具。
Bioinformatics. 2018 Nov 15;34(22):3857-3863. doi: 10.1093/bioinformatics/bty422.
8
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.受体异源二聚体和腺苷酸环化酶功能预偶联复合物的证据。
Nat Commun. 2018 Mar 28;9(1):1242. doi: 10.1038/s41467-018-03522-3.
9
Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease.靶向腺苷A2A和多巴胺D2受体的双效配体的合成及药理学评价，用于帕金森病的潜在治疗
J Med Chem. 2015 Jan 22;58(2):718-38. doi: 10.1021/jm501254d. Epub 2014 Dec 24.
10
The dopamine D2 and adenosine A2A receptors: past, present and future trends for the treatment of Parkinson's disease.多巴胺D2受体与腺苷A2A受体：帕金森病治疗的过去、现在及未来趋势
Curr Med Chem. 2014;21(27):3188-210. doi: 10.2174/1389200215666140217110716.
Zotero 插件