帕博利珠单抗诱发的转移性食管腺癌患者中毒性表皮坏死松解症
Pembrolizumab-induced Toxic Epidermal Necrolysis in a Patient with Metastatic Esophageal Adenocarcinoma.
作者信息
Gallo Marin Benjamin, Oliva Rocío, Kahn Benjamin, Borgovan Theo, Brooks Blake Elizabeth, Massoud Cathy M
机构信息
Brown Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Division of Hematology and Oncology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
出版信息
R I Med J (2013). 2022 Apr 1;105(3):34-36.
Abstract
Adverse cutaneous reactions associated with the immune checkpoint inhibitor (ICI) pembrolizumab are well documented, yet life-threatening reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are infrequent.1,2 We present a case of pembrolizumab-induced TEN in a patient with metastatic esophageal adenocarcinoma who was successfully treated with cyclosporine and systemic corticosteroids.
摘要
与免疫检查点抑制剂（ICI）帕博利珠单抗相关的皮肤不良反应已有充分记录，但诸如史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）等危及生命的反应并不常见。1,2我们报告一例转移性食管腺癌患者发生帕博利珠单抗诱导的TEN，该患者通过环孢素和全身性皮质类固醇成功治愈。
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