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帕博利珠单抗诱发的转移性食管腺癌患者中毒性表皮坏死松解症

Pembrolizumab-induced Toxic Epidermal Necrolysis in a Patient with Metastatic Esophageal Adenocarcinoma.

作者信息

Gallo Marin Benjamin, Oliva Rocío, Kahn Benjamin, Borgovan Theo, Brooks Blake Elizabeth, Massoud Cathy M

机构信息

Brown Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Division of Hematology and Oncology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

出版信息

R I Med J (2013). 2022 Apr 1;105(3):34-36.

PMID:35349618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9053295/
Abstract

Adverse cutaneous reactions associated with the immune checkpoint inhibitor (ICI) pembrolizumab are well documented, yet life-threatening reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are infrequent.1,2 We present a case of pembrolizumab-induced TEN in a patient with metastatic esophageal adenocarcinoma who was successfully treated with cyclosporine and systemic corticosteroids.

摘要

与免疫检查点抑制剂（ICI）帕博利珠单抗相关的皮肤不良反应已有充分记录，但诸如史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）等危及生命的反应并不常见。1,2我们报告一例转移性食管腺癌患者发生帕博利珠单抗诱导的TEN，该患者通过环孢素和全身性皮质类固醇成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50f/9053295/8f39c476f5b8/nihms-1798702-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50f/9053295/986ca20c5e83/nihms-1798702-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50f/9053295/8f39c476f5b8/nihms-1798702-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50f/9053295/986ca20c5e83/nihms-1798702-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b50f/9053295/8f39c476f5b8/nihms-1798702-f0002.jpg

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R I Med J (2013). 2022 Apr 1;105(3):34-36.
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Eur J Case Rep Intern Med. 2024 Nov 28;11(12):005003. doi: 10.12890/2024_005003. eCollection 2024.
3
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本文引用的文献

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J Am Acad Dermatol. 2020 Nov;83(5):1255-1268. doi: 10.1016/j.jaad.2020.03.132. Epub 2020 May 23.
2
Bullous pemphigoid secondary to pembrolizumab mimicking toxic epidermal necrolysis.帕博利珠单抗继发大疱性类天疱疮，酷似中毒性表皮坏死松解症。
JAAD Case Rep. 2020 Apr 29;6(5):400-402. doi: 10.1016/j.jdcr.2020.03.003. eCollection 2020 May.
3
Toxic epidermal necrolysis associated with pembrolizumab.与帕博利珠单抗相关的中毒性表皮坏死松解症。
在使用西米普利单抗治疗皮肤鳞状细胞癌期间，史蒂文斯-约翰逊综合征继发浅表黏液囊肿：一例报告并文献复习
Exp Ther Med. 2024 Nov 18;29(1):15. doi: 10.3892/etm.2024.12765. eCollection 2025 Jan.
4
Stevens-Johnson syndrome and toxic epidermal necrolysis associated with immune checkpoint inhibitors: a systematic review.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症与免疫检查点抑制剂相关：系统评价。
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5
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J Dermatol. 2024 Jan;51(1):3-11. doi: 10.1111/1346-8138.17039. Epub 2023 Nov 30.
6
Causes of Drug-Induced Severe Cutaneous Adverse Reaction Epidermal Necrolysis (EN): An Analysis Using FDA Adverse Event Reporting System (FAERS) Database.药物性严重皮肤不良反应表皮坏死松解症（EN）的病因：使用美国食品药品监督管理局不良事件报告系统（FAERS）数据库进行的分析
Clin Cosmet Investig Dermatol. 2023 Aug 16;16:2249-2257. doi: 10.2147/CCID.S422928. eCollection 2023.
7
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J Oncol Pharm Pract. 2020 Jul;26(5):1259-1265. doi: 10.1177/1078155219890659. Epub 2019 Dec 6.
4
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J Invest Dermatol. 2018 Jun;138(6):1293-1300. doi: 10.1016/j.jid.2017.12.034. Epub 2018 Jan 31.
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Safety Profile of Nivolumab Monotherapy: A Pooled Analysis of Patients With Advanced Melanoma.尼伏鲁单抗单药治疗的安全性概况：晚期黑色素瘤患者的汇总分析。
J Clin Oncol. 2017 Mar;35(7):785-792. doi: 10.1200/JCO.2015.66.1389. Epub 2016 Nov 14.
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Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.抗程序性死亡蛋白1（PD-1）和抗程序性死亡配体1（PD-L1）免疫检查点抗体的毒性。
Ann Oncol. 2015 Dec;26(12):2375-91. doi: 10.1093/annonc/mdv383. Epub 2015 Sep 14.
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Open trial of ciclosporin treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis.环孢素治疗 Stevens-Johnson 综合征和中毒性表皮坏死松解症的开放试验。
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SCORTEN: a severity-of-illness score for toxic epidermal necrolysis.SCORTEN：一种中毒性表皮坏死松解症的疾病严重程度评分系统。
J Invest Dermatol. 2000 Aug;115(2):149-53. doi: 10.1046/j.1523-1747.2000.00061.x.