循环 microRNAs 作为 2 型糖尿病患者冠心病的预测生物标志物。
Circulating microRNAs as predictive biomarkers of coronary artery diseases in type 2 diabetes patients.
机构信息
Department of Clinical Biochemistry, Sarab Faculty of Medical Sciences., Sarab, Iran.
Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran.
出版信息
J Clin Lab Anal. 2022 May;36(5):e24380. doi: 10.1002/jcla.24380. Epub 2022 Mar 29.
BACKGROUND
Type 2 diabetes mellitus (T2DM) is an increasing metabolic disorder mostly resulting from unhealthy lifestyles. T2DM patients are prone to develop heart conditions such as coronary artery disease (CAD) which is a major cause of death in the world. Most clinical symptoms emerge at the advanced stages of CAD; therefore, establishing new biomarkers detectable in the early stages of the disease is crucial to enhance the efficiency of treatment. Recently, a significant body of evidence has shown alteration in miRNA levels associate with dysregulated gene expression occurring in T2DM and CAD, highlighting significance of circulating miRNAs in early detection of CAD arising from T2DM. Therefore, it seems crucial to establish a link between the miRNAs prognosing value and development of CAD in T2DM.
AIM
This study provides an overview on the alterations of the circulatory miRNAs in T2DM and various CADs and consider the potentials of miRNAs as biomarkers prognosing CADs in T2DM patients.
MATERIALS AND METHODS
Literature search was conducted for miRNAs involved in development of T2DM and CAD using the following key words: "miRNAs", "Biomarker", "Diabetes Mellitus Type 2 (T2DM)", "coronary artery diseases (CAD)". Articles written in the English language.
RESULT
There has been shown a rise in miR-375, miR-9, miR-30a-5p, miR-150, miR-9, miR-29a, miR-30d, miR-34a, miR-124a, miR-146a, miR-27a, and miR-320a in T2DM; whereas, miR-126, miR-21, miR-103, miR-28-3p, miR-15a, miR-145, miR-375, miR-223 have been shown to decrease. In addition to T2DM, some miRNAs such as mirR-1, miR-122, miR-132, and miR-133 play a part in development of subclinical aortic atherosclerosis associated with metabolic syndrome. Some miRNAs increase in both T2DM and CAD such as miR-1, miR-132, miR-133, and miR-373-3-p. More interestingly, some of these miRNAs such as miR-92a elevate years before emerging CAD in T2DM.
CONCLUSION
dysregulation of miRNAs plays outstanding roles in development of T2DM and CAD. Also, elevation of some miRNAs such as miR-92a in T2DM patients can efficiently prognose development of CAD in these patients, so these miRNAs can be used as biomarkers in this regard.
背景
2 型糖尿病（T2DM）是一种主要由不健康生活方式引起的代谢紊乱。T2DM 患者易患冠状动脉疾病（CAD）等心脏疾病，CAD 是世界上主要的死亡原因。大多数临床症状出现在 CAD 的晚期阶段；因此，建立可在疾病早期检测到的新生物标志物对于提高治疗效率至关重要。最近，大量证据表明，miRNA 水平的改变与 T2DM 和 CAD 中基因表达失调有关，这突显了循环 miRNA 在早期检测 T2DM 引起的 CAD 中的重要性。因此，建立 miRNA 对 CAD 预测价值与 T2DM 中 CAD 发展之间的联系似乎至关重要。
目的
本研究综述了 T2DM 及各种 CAD 中循环 miRNA 的变化，并探讨了 miRNA 作为 T2DM 患者 CAD 预测标志物的潜力。
材料和方法
使用以下关键词搜索参与 T2DM 和 CAD 发展的 miRNA 的文献：“miRNAs”、“Biomarker”、“Diabetes Mellitus Type 2 (T2DM)”、“coronary artery diseases (CAD)”。只纳入英文文献。
结果
在 T2DM 中，miR-375、miR-9、miR-30a-5p、miR-150、miR-9、miR-29a、miR-30d、miR-34a、miR-124a、miR-146a、miR-27a 和 miR-320a 的水平升高；而 miR-126、miR-21、miR-103、miR-28-3p、miR-15a、miR-145、miR-375 和 miR-223 的水平降低。除 T2DM 外，一些 miRNA，如 mirR-1、miR-122、miR-132 和 miR-133，在代谢综合征相关的亚临床主动脉粥样硬化的发展中也发挥作用。一些 miRNA 在 T2DM 和 CAD 中均升高，如 miR-1、miR-132、miR-133 和 miR-373-3-p。更有趣的是，其中一些 miRNA，如 miR-92a，在 T2DM 出现 CAD 多年前就升高了。
结论
miRNA 的失调在 T2DM 和 CAD 的发展中起着重要作用。此外，T2DM 患者中某些 miRNA（如 miR-92a）的升高可以有效地预测这些患者 CAD 的发展，因此这些 miRNA可在这方面用作生物标志物。
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