Khanbabaei Nafiseh, Mozafar Saadati Hossein, Valizadeh Shahbazloo Shahnam, Hoseinpoor Reyhaneh, Naderi Seyed Hossein, Taghvamanesh Roya, Abolhasani Sakhavat
Department of Clinical Biochemistry - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences.
Department of Epidemiology, School of Public Health and Safety, Tehran.
Cardiovasc Endocrinol Metab. 2020 Aug 13;10(1):45-50. doi: 10.1097/XCE.0000000000000227. eCollection 2021 Mar.
Role of leptin is well documented in cardiometabolic diseases. The objective of this study was to investigate if the serum levels of leptin associates with the serum levels of markers related to cardiac and metabolic disorders in adults.
One hundred eighty subjects [120 cardiovascular disease (CVD) and 60 healthy controls] were enrolled in the study, to determine the association of the serum leptin (in quartiles) and cardiometabolic diseases [metabolic syndrome (MetS) and CVD] adjusted for other biological and physical examination. MetS was according to the WHO Clinical Criteria for MetS definition and CVD by angiography outcomes. The serum levels of leptin and OX-LDL were measured by ELISA.
Leptin levels were significantly higher in patients with MetS and those with positive angiography compared with controls. After controlling for potential confounders, a significant association of the leptin levels with cardiometabolic diseases was proven, albeit there was a higher rate of significance between CVD and leptin in comparison with MetS. Additionally, receiver operating characteristic analysis revealed that the serum levels of leptin were a valuable biomarker of the cardiometabolic diseases.
Our findings demonstrate that serum leptin levels are associated with components of the MetS and with CVD. Serum leptin may be a useful biomarker for CVD.
瘦素在心脏代谢疾病中的作用已有充分记录。本研究的目的是调查成年人血清瘦素水平是否与心脏和代谢紊乱相关标志物的血清水平有关。
180名受试者[120名心血管疾病（CVD）患者和60名健康对照者]参与了本研究，以确定血清瘦素（四分位数）与经其他生物学和体格检查校正后的心脏代谢疾病[代谢综合征（MetS）和CVD]之间的关联。MetS根据世界卫生组织MetS定义的临床标准确定，CVD根据血管造影结果确定。瘦素和氧化型低密度脂蛋白（OX-LDL）的血清水平通过酶联免疫吸附测定（ELISA）法测量。
与对照组相比，MetS患者和血管造影阳性患者的瘦素水平显著更高。在控制潜在混杂因素后，瘦素水平与心脏代谢疾病之间存在显著关联，尽管与MetS相比，CVD与瘦素之间的显著性率更高。此外，受试者工作特征分析显示，血清瘦素水平是心脏代谢疾病的一个有价值的生物标志物。
我们的研究结果表明，血清瘦素水平与MetS的组成成分以及CVD有关。血清瘦素可能是CVD的一种有用的生物标志物。
