Lin Ke, Zhang Hao-Cheng, Zhao Yuan-Han, Xia Jiang, Ai Jing-Wen, Zhang Wen-Hong
Department of Infectious Disease of Huashan Hospital, National Medical Center for Infectious Diseases and Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Fudan University, Shanghai 200040, China.
Pilot Gene Technologies (Hangzhou) Co., Ltd, Hangzhou 310000, China.
J Infect Public Health. 2022 Apr;15(4):450-454. doi: 10.1016/j.jiph.2022.03.008. Epub 2022 Mar 17.
Sepsis is a severe and acute disease associated with high mortality, for those who survive, long-term morbidity. In-time detection of pathogen for proper and optimized treatment in the early stage of sepsis is crucial.
We performed droplet digital PCR (ddPCR) on two cases of sepsis. The clinical information, laboratory test results, and the therapeutic regimen was detailed recorded.
ddPCR showed its clinical value of sepsis ultra-early diagnosis and the guidance of medication in both cases we provided.
ddPCR has potential for rapid and precise diagnose in ultra-early stage of sepsis for its high sensitivity and short turn-around-time, thus benefiting in optimal and timely treatment of sepsis.
脓毒症是一种严重的急性疾病，死亡率高，对于幸存者而言，还会有长期的发病问题。在脓毒症早期及时检测病原体以进行恰当且优化的治疗至关重要。
我们对两例脓毒症患者进行了液滴数字PCR（ddPCR）检测。详细记录了临床信息、实验室检查结果及治疗方案。
在我们提供的两例病例中，ddPCR均显示出其在脓毒症超早期诊断及用药指导方面的临床价值。
ddPCR因其高灵敏度和短周转时间，在脓毒症超早期具有快速、精确诊断的潜力，从而有利于脓毒症的优化及及时治疗。
