Institute of Bioengineering and Bioimaging, 31 Biopolis way, Singapore, 138669, Singapore; Key Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China; College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Institute of Bioengineering and Bioimaging, 31 Biopolis way, Singapore, 138669, Singapore.
Biomaterials. 2022 May;284:121470. doi: 10.1016/j.biomaterials.2022.121470. Epub 2022 Mar 22.
Bacterial and viral infections are posing a huge burden on healthcare industry. Existing antimicrobial textiles that are used to prevent infection transmission are lack of durability and antiviral activity. Here, we report on silane-functionalized polyionenes-coated cotton textiles with durable potent antimicrobial and antiviral activities. To obtain silane-functionalized polyionenes, silane group-containing monomers were synthesized and used to polymerize with co-monomers. These polyionenes were then conjugated onto the surface of cotton fabrics via covalent bonds. These polymers demonstrated broad-spectrum antimicrobial activity against various types of pathogenic microbes as evidenced by low effective concentration. The fabrics coated with these polymers exhibited potent bactericidal (>99.999%) and virucidal (7-log PFU reduction) activities. In addition, the antimicrobial efficacy was still more than 92% even after 50 times of washing. Evaluation of cytocompatibility and skin compatibility of the polymer-coated cotton fabrics in mice revealed that they were compatible with cells and mouse skin, and neither erythema nor edema was found in the area that was in contact with the polymer-coated fabrics. The silane-functionalized polyionenes are potentially promising antimicrobial and antiviral coating materials for textiles and other applications to prevent microbial and viral infections.
细菌和病毒感染给医疗保健行业带来了巨大的负担。现有的用于预防感染传播的抗菌纺织品缺乏耐用性和抗病毒活性。在这里，我们报告了一种具有耐用高效抗菌和抗病毒活性的硅烷功能化聚离子聚合物涂层棉织物。为了获得硅烷功能化聚离子聚合物，合成了含硅烷基团的单体，并与共聚单体聚合。然后，这些聚离子聚合物通过共价键结合到棉织物表面。这些聚合物对各种类型的致病微生物表现出广谱抗菌活性，有效浓度低。涂有这些聚合物的织物表现出强大的杀菌（>99.999%）和杀病毒（7 对数 PFU 减少）活性。此外，即使经过 50 次洗涤，抗菌效果仍超过 92%。在小鼠中对聚合物涂层棉织物的细胞相容性和皮肤相容性进行评估表明，它们与细胞和小鼠皮肤相容，与聚合物涂层织物接触的区域既没有红斑也没有水肿。硅烷功能化聚离子聚合物是一种有潜力的抗菌和抗病毒涂层材料，可用于纺织品和其他应用，以预防微生物和病毒感染。
