Obiofuma Chukwuka, Dy Christopher, Iannucci Leanne E, Lake Spencer P, Brogan David
Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, Mo.
Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Mo.
Plast Reconstr Surg Glob Open. 2022 Mar 24;10(3):e4177. doi: 10.1097/GOX.0000000000004177. eCollection 2022 Mar.
Although extensive research shows an association between distal radius fractures and the development of median nerve related pathologies such as carpal tunnel syndrome, none directly track how the resulting angular deformity relates to likelihood of development of median nerve pathology.
Median nerve strain was measured with a custom-built system using a camera, optical markers, and a proprietary segmentation algorithm. After initial validation of the system in a cadaver model, our system was used to assess strain in 10 cadaver arms with a simulated distal radius fracture and increasing dorsal angulation. The measured strain at each angle was then analyzed using a linear regression model.
The linear regression model in the validation experiment demonstrated a regression coefficient of 1.00067 ( < 0.0001) with r = 0.899, thus validating the use of the optical tracking system. The average strain at maximum dorsal angulation (50 degrees) across all specimens was -0.2%. Linear regression analysis of the effect of increasing dorsal angulation on strain in the osteotomy model yielded a regression coefficient of -0.000048 ( = 0.714), r = 0.00129, suggesting no significant correlation between increasing dorsal tilt and median nerve strain.
Increases in median nerve strain at the wrist are negligible with increasing dorsal tilt in a distal radius fracture model. It is therefore likely that other factors, such as increased pressure within the carpal tunnel, are the primary cause of median neuropathy in distal radius malunions. Therefore, correction of dorsal tilt may not be required to improve neurologic symptoms.
尽管大量研究表明桡骨远端骨折与正中神经相关病变(如腕管综合征)的发生之间存在关联,但尚无研究直接追踪由此产生的角畸形与正中神经病变发生可能性之间的关系。
使用定制系统,通过相机、光学标记和专有分割算法测量正中神经应变。在尸体模型中对该系统进行初步验证后,我们的系统用于评估10个带有模拟桡骨远端骨折且背侧成角增加的尸体手臂的应变。然后使用线性回归模型分析每个角度测量的应变。
验证实验中的线性回归模型显示回归系数为1.00067(<0.0001),r = 0.899,从而验证了光学跟踪系统的使用。所有标本在最大背侧成角(50度)时的平均应变是-0.2%。在截骨模型中,背侧成角增加对应变影响的线性回归分析得出回归系数为-0.000048(= 0.714),r = 0.00129,表明背侧倾斜增加与正中神经应变之间无显著相关性。
在桡骨远端骨折模型中,随着背侧倾斜增加,腕部正中神经应变的增加可忽略不计。因此,腕管内压力增加等其他因素可能是桡骨远端畸形愈合中正中神经病变的主要原因。所以,可能不需要纠正背侧倾斜来改善神经症状。