Cunningham M, Berrut C
Schweiz Med Wochenschr. 1986 Sep 27;116(39):1349-52.
Gastro-oesophageal reflux (GOR) occurs with increased frequency in asthmatics. GOR may cause pulmonary symptoms either by reflux of gastric contents into the trachea or by a reflex mechanism. Several studies have shown that the presence of acid in the oesophagus may induce slight bronchospasm. However, more recent studies have clearly demonstrated that acidification of the oesophagus may exacerbate the bronchial hyperreactivity characteristic of the asthmatic patient, thus rendering the patient more susceptible to bronchoconstriction by other stimuli. As some drugs used in the treatment of asthma decrease lower oesophageal sphincter pressure and thereby enhance GOR, a vicious circle may arise. As surgical and medical anti-reflux therapy has been shown to be effective in diminishing asthmatic symptoms in the asthmatic patient with proven GOR, 24-hour ambulatory oesophageal pH monitoring is recommended in order to detect such patients and give them a trial with an H2 receptor antagonist.
胃食管反流（GOR）在哮喘患者中出现的频率增加。GOR可能通过胃内容物反流至气管或通过反射机制引起肺部症状。多项研究表明，食管内存在酸可能诱发轻微支气管痉挛。然而，最近的研究清楚地表明，食管酸化可能会加剧哮喘患者的支气管高反应性，从而使患者更容易受到其他刺激引起的支气管收缩。由于一些用于治疗哮喘的药物会降低食管下括约肌压力，从而增强GOR，可能会形成恶性循环。鉴于手术和药物抗反流治疗已被证明对确诊为GOR的哮喘患者减轻哮喘症状有效，建议进行24小时动态食管pH监测，以检测此类患者，并给予他们使用H2受体拮抗剂进行试验。
