Arnouk Sana, De Groof Timo W M, Van Ginderachter Jo A
Cellular and Molecular Immunology Lab, Vrije Universiteit Brussel, Brussels, Belgium; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.
In Vivo Cellular and Molecular Imaging Lab, Department of Medical Imaging, Vrije Universiteit Brussel, Brussels, Belgium.
Adv Drug Deliv Rev. 2022 May;184:114239. doi: 10.1016/j.addr.2022.114239. Epub 2022 Mar 26.
The important role of tumor microenvironmental elements in determining tumor progression and metastasis has been firmly established. In particular, the presence and activity profile of tumor-infiltrating immune cells may be associated with the outcome of the disease and may predict responsiveness to (immuno)therapy. Indeed, while some immune cell types, such as macrophages, support cancer cell outgrowth and mediate therapy resistance, the presence of activated CD8 T cells is usually indicative of a better prognosis. It is therefore of the utmost interest to obtain a full picture of the immune infiltrate in tumors, either as a prognostic test, as a way to stratify patients to maximize therapeutic success, or as therapy follow-up. Hence, the non-invasive imaging of these cells is highly warranted, with biologics being prime candidates to achieve this goal.
肿瘤微环境因素在决定肿瘤进展和转移方面的重要作用已得到确凿证实。特别是，肿瘤浸润免疫细胞的存在和活性特征可能与疾病的预后相关，并可预测对（免疫）治疗的反应性。事实上，虽然某些免疫细胞类型，如巨噬细胞，支持癌细胞生长并介导治疗耐药性，但活化的CD8 T细胞的存在通常预示着较好的预后。因此，全面了解肿瘤中的免疫浸润情况极具意义，无论是作为一种预后检测方法、一种对患者进行分层以最大化治疗成功几率的方式，还是作为治疗随访手段。因此，对这些细胞进行非侵入性成像非常必要，生物制剂是实现这一目标的主要候选者。
