Demchenko A P, Kostrzhevskaia E G
Ukr Biokhim Zh (1978). 1986 Sep-Oct;58(5):92-103.
The paper is concerned with the analysis of the present data as to the structure and properties of melittin, a biologically active peptide of bee venom, able to be inserted spontaneously into the natural and synthetic membranes and to destruct cells in micromolar concentrations. This property is a result of the peptide structure peculiarities. Attention is focused on the mechanism of melittin insertion into the phospholipid bilayer as well as on the possibility of its use to study the nature of protein-lipid interactions and formation of ionic channels.
本文关注对当前数据的分析，这些数据涉及蜂毒明肽的结构和特性。蜂毒明肽是一种具有生物活性的蜂毒肽，能够自发插入天然和合成膜中，并在微摩尔浓度下破坏细胞。这种特性是肽结构特点的结果。注意力集中在蜂毒明肽插入磷脂双层的机制以及其用于研究蛋白质 - 脂质相互作用性质和离子通道形成的可能性上。
