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A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues.

作者信息

Yi Chunyan, Ling Zhiyang, Lu Xiao, Fu Yadong, Yang Zhuo, Wangmo Sonam, Chen Shuangfeng, Zhang Yaguang, Ma Liyan, Gu Wangpeng, Lu Hongzhou, Sun Xiaoyu, Sun Bing

机构信息

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.

出版信息

Cell Mol Immunol. 2022 May;19(5):647-649. doi: 10.1038/s41423-022-00853-6. Epub 2022 Mar 29.

DOI:10.1038/s41423-022-00853-6
PMID:35352009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8961485/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a5/9061748/3f6388116249/41423_2022_853_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a5/9061748/3f6388116249/41423_2022_853_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5a5/9061748/3f6388116249/41423_2022_853_Fig1_HTML.jpg

相似文献

[1]
A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues.

Cell Mol Immunol. 2022-5

[2]
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer.

J Virol. 2022-8-24

[3]
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.

Proc Natl Acad Sci U S A. 2023-12-26

[4]
Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.

EMBO Mol Med. 2021-12-7

[5]
A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern.

J Virol. 2022-8-24

[6]
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope.

Cell Host Microbe. 2022-6-8

[7]
Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants.

PLoS Pathog. 2023-11

[8]
Novel Affibody Molecules Specifically Bind to SARS-CoV-2 Spike Protein and Efficiently Neutralize Delta and Omicron Variants.

Microbiol Spectr. 2023-2-14

[9]
A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses.

Nat Commun. 2024-6-15

[10]
Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75.

Cell Host Microbe. 2022-11-9

引用本文的文献

[1]
Efficient discovery of frequently co-occurring mutations in a sequence database with matrix factorization.

PLoS Comput Biol. 2025-4-24

[2]
The recombinant spike S1 protein induces injury and inflammation in co-cultures of human alveolar epithelial cells and macrophages.

PLoS One. 2025-2-10

[3]
Engineered Multivalent Nanobodies Efficiently Neutralize SARS-CoV-2 Omicron Subvariants BA.1, BA.4/5, XBB.1 and BQ.1.1.

Vaccines (Basel). 2024-4-15

[4]
Effect of second booster vaccination on clinical outcomes of Omicron-variant breakthrough infection: A propensity score matching cohort study.

Heliyon. 2023-12-7

[5]
Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant-infected adults: A real-world cohort study.

Clin Respir J. 2023-10

[6]
Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies.

Sci China Life Sci. 2023-4

[7]
Vitamin D levels and clinical outcomes of SARS-CoV-2 Omicron subvariant BA.2 in children: A longitudinal cohort study.

Front Nutr. 2022-7-25

[8]
Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape.

Cell Mol Immunol. 2022-7

本文引用的文献

[1]
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2.

Cell. 2022-2-17

[2]
T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant.

Cell Mol Immunol. 2022-3

[3]
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2.

Nature. 2022-2

[4]
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift.

Nature. 2022-2

[5]
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.

Nature. 2022-2

[6]
The electrostatic potential of the Omicron variant spike is higher than in Delta and Delta-plus variants: A hint to higher transmissibility?

J Med Virol. 2022-4

[7]
Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants.

Genome Med. 2021-10-14

[8]
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.

Science. 2020-6-15

[9]
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.

Nature. 2020-5-26

[10]
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.

Nature. 2020-5-18

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