Krikken Jan A, van den Heuvel Ad F M, Willemsen H Marco, Voors Adriaan A, Lipsic Erik
Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Neth Heart J. 2022 Sep;30(9):393-399. doi: 10.1007/s12471-022-01673-z. Epub 2022 Mar 29.
Despite the high prevalence and adverse clinical outcomes of severe tricuspid regurgitation (TR), conventional treatment options, surgical or pharmacological, are limited. Surgery is associated with a high peri-operative risk and medical treatment has not clearly resulted in clinical improvements. Therefore, there is a high unmet need to reduce morbidity and mortality in patients with severe TR. During recent years, several transcatheter solutions have been studied. This review focuses on the transcatheter edge-to-edge repair of TR (TTVR) with respect to patient selection, the procedure, pre- and peri-procedural echocardiographic assessments and clinical outcomes. Furthermore, we highlight the current status of TTVR in the Netherlands and provide data from our initial experience at the University Medical Centre Groningen.
尽管严重三尖瓣反流（TR）的患病率很高且临床预后不良，但传统的治疗选择，无论是手术还是药物治疗，都很有限。手术与围手术期高风险相关，而药物治疗并未明显带来临床改善。因此，对于降低严重TR患者的发病率和死亡率，存在着很大的未满足需求。近年来，已经研究了几种经导管解决方案。本综述重点关注TR的经导管缘对缘修复术（TTVR），涉及患者选择、手术过程、术前和围手术期超声心动图评估以及临床结果。此外，我们强调了荷兰TTVR的现状，并提供了格罗宁根大学医学中心的初步经验数据。
