College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Chem Commun (Camb). 2022 Apr 14;58(31):4813-4824. doi: 10.1039/d2cc00147k.
The field of force-induced release of small cargoes within polymeric materials has experienced rapid growth over the past decade, not only including achieving diversified functional materials that report force, trigger degradation, activate drugs and release catalysts, but also involving investigations on the interesting force-coupled reactivity of mechanophores, such as ferrocenes. In this highlight article, we review the recent progress on polymer mechanochemistry that releases small cargoes, including small molecules and metal ions. Since mechanophores play a key role in force-responsive materials, we introduce the progress by discussing different types of mechanophores and their mechanochemical reactions for the release of acids, gases, fluorophores, drugs, iron ions, and so on. At the end, we provide our perspectives on the remaining challenges and future targets in this growing field.
在过去的十年中，力致小分子释放的研究领域在聚合材料中得到了快速发展，不仅包括实现了多种功能材料，如报告力、触发降解、激活药物和释放催化剂，还涉及到对机械试剂的有趣的力偶合反应的研究，如二茂铁。在这篇重点文章中，我们回顾了近年来关于释放小分子（包括小分子和金属离子）的聚合物机械化学的最新进展。由于机械试剂在力响应材料中起着关键作用，我们通过讨论不同类型的机械试剂及其机械化学反应来介绍这方面的进展，这些反应可用于释放酸、气体、荧光团、药物、铁离子等。最后，我们对这一不断发展的领域中仍然存在的挑战和未来目标提出了看法。
