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公共卫生系统中一组老年艾滋病毒/艾滋病患者的流行病学特征及依从性

Epidemiological characteristics and adherence of a cohort of elderly people with HIV/AIDS in the Public Health System.

作者信息

Ferreira Cristiane Marcos Soares Dias, Leite Isabel Cristina Gonçalves

机构信息

Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.

出版信息

Einstein (Sao Paulo). 2022 Mar 25;20:eAO6474. doi: 10.31744/einstein_journal/2022AO6474. eCollection 2022.

Abstract

OBJECTIVE

To characterize the epidemiological profile of patients aged 50 years or older diagnosed as HIV/AIDS, in a Specialized Service of the Public Health System.

METHODS

A retrospective cohort study using secondary data from medical records in the period 2014 to 2018. Sociodemographic and clinical characteristics, and features related to treatment adherence were organized in a database. Quantitative variables were expressed as mean (or median) ± standard deviation (or interquartile range), and categorical variables expressed as number and percentage of patients. The Kaplan-Meier method was applied to assess the probability of overall specific survival.

RESULTS

Of the 241 initially eligible patients, 149 patients were evaluated, registering 19 deaths in the studied period. There was a predominance of males aged 50-59 years, with severe immunodeficiency upon admission (29.7%), and with a CD4+ T lymphocyte count below 200 cells in 62 (46.3%) of patients. Elderly people aged 61 or over were more adherent. There was an increase in the CD4+ T lymphocyte count by an average of 139.63 in the first 6 months, and 50.51 from the first 6 months to 12 months of follow-up, with an average increase in the first 12 months of 157.63 cells. Specific overall survival in the period was 85%.

CONCLUSION

Patients older than 50 years had an immune response and no viral load detection in the 12-month period, deserving further studies to improve survival.

摘要

目的

在公共卫生系统的一个专业服务机构中,描述年龄在50岁及以上被诊断为艾滋病毒/艾滋病患者的流行病学特征。

方法

采用回顾性队列研究,使用2014年至2018年期间医疗记录中的二手数据。社会人口统计学和临床特征以及与治疗依从性相关的特征被整理到一个数据库中。定量变量以均值(或中位数)±标准差(或四分位间距)表示,分类变量以患者数量和百分比表示。应用Kaplan-Meier方法评估总体特定生存率。

结果

在最初符合条件的241名患者中,有149名患者接受了评估,在研究期间记录到19例死亡。50 - 59岁男性占主导,入院时存在严重免疫缺陷(29.7%),62名(46.3%)患者的CD4 + T淋巴细胞计数低于200个细胞。61岁及以上的老年人依从性更高。在随访的前6个月,CD4 + T淋巴细胞计数平均增加139.63,从第6个月到第12个月平均增加50.51,在12个月内平均增加157.63个细胞。该期间的总体特定生存率为85%。

结论

50岁以上患者在12个月期间有免疫反应且未检测到病毒载量,值得进一步研究以提高生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c2e/8932733/d48efd2caed4/2317-6385-eins-20-eAO6474-gf01.jpg

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