Vial P A, Ferreccio C, Abarca K, Ortiz E, Noriega M, Pérez C, Labarca J, Torres M, Ferrés M, González C, Acuña G
Facultad de Medicina, P'ontificia Universidad Católica de Chile.
Rev Med Chil. 1996 May;124(5):525-35.
We characterized clinical manifestations and the risk to develop AIDS in a cohort of 32 patients infected with human immunodeficiency virus without AIDS A multivariate analysis was performed to determine association between the progression of infection and control variables (socioeconomic level, age, sex and sexual preferences) and causal variables (psycho-social changes, significant clinical events, stress scoring and sexual activity). The cumulative AIDS incidence, defined as a CD4 lymphocyte count below 200 cells/cm3 was 50% at 6.5 years and 82% at 8 years. Using clinical criteria to define AIDS, 50% developed the disease at 8 years of follow up. Among studied factors, only age (faster progression at higher age) and time of evolution were associated with progression in stages before AIDS, the most frequent diseases were acute diarrhea, sexual transmission diseases, oral candidiasis, sinusitis and varicella zoster infections. The reduction; of CD4 lymphocytes-below 200 cells/cm3 always preceded the symptoms of the disease. Two patients have remained more than eight years without clinical or immunological deterioration.
我们对32例未患艾滋病的人类免疫缺陷病毒感染者队列的临床表现及患艾滋病风险进行了特征描述。进行了多变量分析，以确定感染进展与控制变量（社会经济水平、年龄、性别和性取向）以及因果变量（心理社会变化、重大临床事件、压力评分和性活动）之间的关联。定义为CD4淋巴细胞计数低于200个细胞/立方厘米的累积艾滋病发病率在6.5年时为50%，在8年时为82%。使用临床标准定义艾滋病，50%的患者在随访8年时患上该病。在所研究的因素中，只有年龄（年龄越大进展越快）和病程与艾滋病前阶段的进展相关，最常见的疾病是急性腹泻、性传播疾病、口腔念珠菌病、鼻窦炎和水痘带状疱疹感染。CD4淋巴细胞减少至低于200个细胞/立方厘米总是先于疾病症状出现。两名患者已超过八年没有临床或免疫功能恶化。
