Dieckmann A, Jung A
Z Parasitenkd. 1986;72(5):591-4. doi: 10.1007/BF00925479.
Highly synchronous cultures of Plasmodium falciparum were exposed to therapeutic concentrations of sulfadoxine or pyrimethamine at different developmental stages to investigate the effect on subsequent growth. Morphological observations showed that schizont formation from uninuclear trophozoites was the only process inhibited by the drugs. Segmentation of mature schizonts, merozoite invasion and development of the ring stage remained unaffected. These results support earlier reports suggesting that DNA synthesis is most pronounced in 32-42 h old trophozoites. The possible relevance of our results to the metabolism of P. falciparum is discussed.
将恶性疟原虫的高度同步培养物在不同发育阶段暴露于治疗浓度的磺胺多辛或乙胺嘧啶中，以研究对后续生长的影响。形态学观察表明，从单核滋养体形成裂殖体是唯一受药物抑制的过程。成熟裂殖体的分裂、裂殖子入侵和环状体发育均未受影响。这些结果支持了早期的报告，即DNA合成在32-42小时龄的滋养体中最为明显。讨论了我们的结果与恶性疟原虫代谢的可能相关性。
