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自体牙本质和富血小板纤维蛋白复合移植物修复创伤性下颌骨囊肿缺损:一例报告。

Traumatic Mandibular Cyst Defect Grafted with Autologous Dentin and Platelet-Rich Fibrin Composite: A Case Report.

出版信息

Int J Periodontics Restorative Dent. 2022 Mar-Apr;42(2):253-259. doi: 10.11607/prd.5215.

DOI:10.11607/prd.5215
PMID:35353096
Abstract

Some cases of asymptomatic traumatic cyst can be sizable; therefore, they require complete curettage and grafting with bone substitution materials. This case report presents a sizeable traumatic mandibular cyst in a young man treated by surgical exploration and filled with autologous dentin graft (ADG) prepared from an extracted impacted tooth 48 (FDI tooth-numbering system) and advanced platelet-rich fibrin (A-PRF). Initially, an A-PRF membrane was used to cover the apices of teeth 42 and 43, which were protruding into the defect to protect their periapical structures. Then, a grafting strategy was introduced to achieve two fronts of bone formation: one by stimulation of bone outgrowth from the periphery due to A-PRF cellular activity, and a second by bone deposition directly on dentin particles in the center of the defect. On CBCT scans performed 7 months postoperatively, arrays of trabeculae that were extending from bone boundaries of the cyst defect were merged with more condensed bone deposited on ADG residuals in the center, thus filling the defect. It was found that autologous dentin combined with cellular A-PRF activity is a powerful tool to restore even sizable bone defects in a relatively short time frame with adequate bone remodeling.

摘要

一些无症状创伤性囊肿可能较大;因此,需要彻底刮除并用骨替代材料进行移植。本病例报告介绍了一例年轻男性的较大创伤性下颌骨囊肿,采用手术探查和用取自已拔除的埋伏牙 48(FDI 牙编号系统)的自体牙本质移植物(ADG)和富血小板纤维蛋白(A-PRF)填充进行治疗。最初,使用 A-PRF 膜覆盖 42 和 43 号牙的根尖,这些牙向缺损处突出以保护其根尖结构。然后,引入了一种移植策略来实现两个骨形成前缘:一是通过 A-PRF 细胞活性刺激骨从外周向外生长,二是通过直接在缺损中心的牙本质颗粒上沉积骨。术后 7 个月的 CBCT 扫描显示,从囊肿缺损骨边界延伸的小梁排列与中心 ADG 残余物上沉积的更致密的骨合并,从而填充了缺损。结果发现,自体牙本质与细胞 A-PRF 活性相结合是一种强大的工具,可在相对较短的时间内恢复甚至较大的骨缺损,并进行充分的骨重塑。

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