Gabrielian E S, Akopov S E, Tunian Iu S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(9):1340-3.
The authors studied the interaction between red blood cells (RBCs) and prostacycline (P) in normal subjects and patients with transient disorders of the cerebral circulation and cerebral stroke. RBCs accelerated P disintegration with the formation of inactive products, with the process being most accelerated in RBC aggregation. It has been found that hyperosmolarity of the medium and disoxygenation of RBCs increase their ability to break down P while lactacydosis decreases this ability. It has been also established that there is a greater proportion of people with a marked ability of RBCs to break down P among patients with cerebral dyshemias, particularly with cerebral stroke. This might be due to alterations in the conformation of the surface layers of RBCs in abnormal conditions.
作者研究了正常受试者以及患有短暂性脑循环障碍和脑卒中患者的红细胞（RBC）与前列环素（P）之间的相互作用。红细胞加速了P的分解并形成无活性产物，在红细胞聚集时该过程加速最为明显。研究发现，介质的高渗和红细胞的脱氧会增加其分解P的能力，而酸中毒则会降低这种能力。还确定在脑供血不足患者中，尤其是脑卒中患者中，具有明显红细胞分解P能力的人所占比例更大。这可能是由于在异常情况下红细胞表层构象发生了改变。
