Akopov S E, Gabrielian E S, Tunian Iu S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(8):1146-50.
It has been shown that patients with cerebral ischemias are characterized by a reduction in the capacity of prostacyclin to inhibit platelet aggregation and a decrease in the time of its plasma half-life. The role of these changes in the pathogenesis of cerebral circulation disturbances is discussed. It has been established that cases of the most pronounced decrease in the antiaggregation effect of prostacyclin with its minimum stability in the plasma are the least favourable with regard to the prognosis of cerebral infarction. It is suggested that disorders of the function of the prostacyclin system (regulation of the equilibrium between platelets and the vessel wall) may be latent, predetermining a high risk of the development of thrombotic disorders.
研究表明，脑缺血患者的特征是前列环素抑制血小板聚集的能力降低，其血浆半衰期缩短。文中讨论了这些变化在脑循环障碍发病机制中的作用。已经确定，前列环素抗聚集作用最显著降低且在血浆中稳定性最低的病例，其脑梗死预后最不理想。有人认为，前列环素系统功能紊乱（血小板与血管壁之间平衡的调节）可能是潜在的，预示着血栓形成疾病发生的高风险。
