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环境丰容与氟西汀在抑制小鼠蔗糖寻求更新中的相互作用取决于社会生活条件。

The interaction between Environmental Enrichment and fluoxetine in inhibiting sucrose-seeking renewal in mice depend on social living condition.

机构信息

Section of Pharmacology, Department of Diagnostic and Public Health, Policlinico 'GB Rossi', P.le Scuro 10, University of Verona, 37134, Verona, Italy.

Department of Biomedical Sciences, Cittadella Universitaria Di Monserrato, University of Cagliari, S.P.8 km 0, 700-09042, Monserrato, Cagliari, Italy.

出版信息

Psychopharmacology (Berl). 2022 Jul;239(7):2351-2361. doi: 10.1007/s00213-022-06124-6. Epub 2022 Mar 30.

Abstract

RATIONALE

Several single or combined therapeutic approaches have been developed to treat addiction, however with partial efficacy in preventing relapse. Recently, the living environment has been suggested as a critical intervening factor determining the treatment outcomes. Despite accumulating evidence confirming a role of living conditions in the vulnerability to addictive behaviours, their impact on single or integrative therapeutic strategies preventing relapse is yet to be identified.

OBJECTIVES

Here, we explore the possible interaction between brief Environmental Enrichment (EE) exposure and acute fluoxetine administration in inhibiting sucrose-seeking behaviours, and whether this effect could be affected by living environment.

METHODS

Social and isolated adult male C57BL/6 mice were trained to sucrose self-administration associated to a specific conditioning context (CxA), followed by a 7-day extinction in a different context (CxB). Afterwards, mice were exposed for 22 h to EE and then injected with fluoxetine (10 mg/kg, i.p.) 1 h before a CxA-induced sucrose-seeking test.

RESULTS

Brief EE exposure and acute fluoxetine administration alone inhibited context-induced sucrose-seeking in both housing conditions; however, they exhibited additive properties only in social condition.

CONCLUSIONS

Our data show that social environment may influence the EE/fluoxetine interaction in inhibiting relapse to sucrose. These findings suggest that setting up proper living conditions to boost the efficacy of therapeutic approaches may represent a fundamental strategy to treat addiction disorders.

摘要

原理

已经开发出几种单一或联合的治疗方法来治疗成瘾,然而在预防复发方面只有部分疗效。最近,生活环境被认为是决定治疗结果的一个关键干预因素。尽管越来越多的证据证实了生活条件在易患成瘾行为方面的作用,但它们对单一或综合治疗策略预防复发的影响尚未确定。

目的

在这里,我们探讨了短暂的环境丰富(EE)暴露和急性氟西汀给药在抑制蔗糖寻求行为方面的可能相互作用,以及这种效应是否会受到生活环境的影响。

方法

社交和隔离的成年雄性 C57BL/6 小鼠接受蔗糖自我给药训练,与特定的条件环境(CxA)相关联,然后在不同的环境(CxB)中进行 7 天的消退。之后,将小鼠暴露于 EE 22 小时,然后在 CxA 诱导的蔗糖寻求测试前 1 小时注射氟西汀(10mg/kg,ip)。

结果

单独的短暂 EE 暴露和急性氟西汀给药抑制了两种环境下的环境诱导的蔗糖寻求;然而,它们仅在社交环境中表现出相加作用。

结论

我们的数据表明,社交环境可能会影响 EE/氟西汀相互作用在抑制蔗糖复吸中的作用。这些发现表明,建立适当的生活条件以提高治疗方法的疗效可能是治疗成瘾障碍的一种基本策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250c/9205808/1b3a4f1a01c4/213_2022_6124_Fig1_HTML.jpg

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