Prevention Science Group, Oxford Brookes University, Oxford, UK.
J Adolesc. 2022 Feb;94(2):240-252. doi: 10.1002/jad.12023. Epub 2022 Feb 14.
The effect of socioeconomic status on adolescent substance abuse may be mediated by family socialization practices. However, traditional mediation analysis using a product or difference method is susceptible to bias when assumptions are not addressed. We aimed to use a potential outcomes framework to assess assumptions of exposure-mediator interaction and of no confounding of the results.
We revisited a traditional mediation analysis with a multiple mediator causal mediation approach using data from 17,761 Norwegian young people (13-18 years), 51% female. Data were collected through a print questionnaire. Socioeconomic status was operationalized as parental education and employment status (employed or receiving welfare); drinking behavior as the frequency of alcohol consumption and frequency of intoxication in the past year; and socialization practices as general parenting measures, alcohol-related parental permissiveness, and parent drinking behavior.
There was no consistent evidence of exposure-mediator interaction. Formal sensitivity analysis of mediator-outcome confounding was not possible in the multiple mediator model, and this analysis supported the hypothesis that socioeconomic status effects on adolescent substance abuse are fully mediated by family socialization practices, with apparently stronger effects in younger age groups observed in plots.
We found that the effect of socioeconomic status on adolescent substance abuse was fully mediated by family socialization practices. While our analysis provides more rigorous support for causal inferences than past work, we could not completely rule out the possibility of unmeasured confounding.
社会经济地位对青少年物质滥用的影响可能通过家庭社会化实践来调节。然而,当假设未得到解决时,传统的基于乘积或差的中介分析方法容易产生偏差。我们旨在使用潜在结果框架来评估暴露-中介相互作用的假设以及结果是否存在混杂。
我们使用来自 17761 名挪威年轻人(13-18 岁,51%为女性)的数据,通过多中介因果中介分析方法,重新进行了传统的中介分析。数据通过纸质问卷收集。社会经济地位由父母的教育和就业状况(就业或领取福利)来操作化;饮酒行为由饮酒频率和过去一年的醉酒频率来衡量;社会化实践由一般的育儿措施、与酒精相关的父母宽容度和父母饮酒行为来衡量。
没有一致的证据表明存在暴露-中介相互作用。在多中介模型中,对中介-结局混杂的正式敏感性分析是不可能的,该分析支持了这样的假设,即社会经济地位对青少年物质滥用的影响完全由家庭社会化实践来调节,在年龄较小的年龄组中观察到的效应更强。
我们发现,社会经济地位对青少年物质滥用的影响完全由家庭社会化实践来调节。虽然我们的分析比以往的工作提供了更严格的因果推断支持,但我们不能完全排除存在未测量混杂的可能性。