Structural and Functional Interactions in Rehabilitation-UNIMAR, Marília, São Paulo, Brazil.
Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.
J Med Food. 2022 Aug;25(8):797-806. doi: 10.1089/jmf.2021.0084. Epub 2022 Mar 28.
Advancing age is one of the risk factors for developing many diseases, including cancer, cardiovascular disorders, and neurodegenerative alterations, such as mild cognitive impairment (MCI), and Alzheimer's Disease (AD). Studies have indicated that supplementation with resveratrol (RSV) might improve cerebrovascular function and reduce the risk of developing dementia. Thus, the aim of this systematic review was to assess the effects of RSV on MCI and AD. MEDLINE-PubMed, Cochrane, and EMBASE were used to perform the search, and PRISMA guidelines were followed. Five studies met the eligible criteria; three with AD and two with MCI. In AD patients, the use of RSV reduces A levels, improves brain volume, reduces the Mini-mental status score, and improves AD scores. In patients with MCI, this polyphenol prevents decline in Standard Volumes of Interest and increases the Resting-state Functional Connectivity score. RSV can activate the human silent information regulator 2/sirtuin 1 (Sirt-1) and can inhibit the cyclooxygenase-2 (COX-2), 5-lipoxygenase, and nuclear factor-B, resulting in the reduction of the proinflammation pathways. It is also associated with the increase in the levels of interleukin (IL)-10 and reduction of interferon- and IL-17. Both anti-inflammatory and antioxidant effects can be related to preventing neurodegenerative diseases, doing maintenance, and enabling the recovery of these conditions directly related to inflammation and oxidative stress. We suggest that the use of RSV can bring beneficial effects to patients with MCI or AD.
随着年龄的增长，许多疾病的发病风险也随之增加，包括癌症、心血管疾病和神经退行性改变，如轻度认知障碍（MCI）和阿尔茨海默病（AD）。研究表明，白藜芦醇（RSV）的补充可能改善脑血管功能，降低痴呆的发病风险。因此，本系统评价的目的是评估 RSV 对 MCI 和 AD 的影响。我们使用 MEDLINE-PubMed、Cochrane 和 EMBASE 进行了检索，并遵循了 PRISMA 指南。符合纳入标准的研究有 5 项，其中 3 项为 AD 患者，2 项为 MCI 患者。在 AD 患者中，RSV 的使用可以降低 A 水平，增加脑容量，降低 Mini-mental 状态评分，改善 AD 评分。在 MCI 患者中，这种多酚可以防止标准感兴趣区的下降，并增加静息状态功能连接评分。RSV 可以激活人沉默信息调节因子 2/沉默调节蛋白 1（Sirt-1），并抑制环氧化酶-2（COX-2）、5-脂氧合酶和核因子-B，从而减少促炎途径。它还与白细胞介素（IL）-10 水平的增加和干扰素和 IL-17 的减少有关。抗炎和抗氧化作用都与预防神经退行性疾病、维持和恢复与炎症和氧化应激直接相关的疾病有关。我们建议，RSV 的使用可能对 MCI 或 AD 患者有益。
