Edwards R H
Acta Med Scand Suppl. 1986;711:179-88. doi: 10.1111/j.0954-6820.1986.tb08948.x.
Muscle fatigue and pain are together common symptoms which can be analysed physiologically. For many patients attending a medical clinic the problem for the doctor is to decide whether the problem is "in the mind" or "in the muscle". A history of the symptoms occurring at rest without any exercise is a hint of psychological origin. Exercise fatigue or pain should ideally be reproduced by an appropriate provoking exercise test. Needle biopsy with histochemistry is cost-effective as a means of reaching a diagnosis while blood determinations of erythrocyte sedimentation rate and plasma creatine kinase and lactate are more specific but less sensitive indicators of a muscle cause. Fatigue is analysed by force and action potential measurements with electrically stimulated contractions. Pain worse after exercise can be related to muscle damage. A programme of therapeutic exercise may be tried as a further means of assessment of these symptoms.
肌肉疲劳和疼痛是常见症状，可从生理学角度进行分析。对于许多前往医疗诊所就诊的患者而言，医生面临的问题是判断问题是“心理因素所致”还是“肌肉因素所致”。休息时无任何运动却出现症状的病史提示可能源于心理因素。理想情况下，运动疲劳或疼痛应通过适当的激发运动试验重现。针吸活检及组织化学检查作为一种诊断手段性价比高，而血液中红细胞沉降率、血浆肌酸激酶和乳酸的测定是肌肉病因更具特异性但敏感性较低的指标。通过电刺激收缩时的力量和动作电位测量来分析疲劳。运动后疼痛加剧可能与肌肉损伤有关。可以尝试进行治疗性运动方案，作为评估这些症状的进一步手段。
