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疱疹样皮炎作为静脉注射免疫球蛋白(IVIg)的副作用。

Pompholyx as a side effect of intravenous immunoglobulin (IVIg).

机构信息

Dermatology, Beaumont Hospital, Dublin, Ireland

Dermatology, Beaumont Hospital, Dublin, Ireland.

出版信息

BMJ Case Rep. 2022 Mar 30;15(3):e248772. doi: 10.1136/bcr-2022-248772.

Abstract

Intravenous immunoglobulin (IVIg) is increasingly used across multiple specialties for the treatment of inflammatory and autoimmune diseases. Cutaneous reactions to IVIg are generally minor. Pompholyx is a common eruption of small vesicles on the palms, soles, and/or lateral aspects of the fingers. It has a multifactorial aetiology but is rarely attributed to being a drug-related side effect. We describe a 43-year-old woman presenting with peripheral sensory neuropathy who developed pompholyx eczema on both palms following treatment with IVIg.

摘要

静脉注射免疫球蛋白(IVIg)在多个医学专业领域中越来越多地被用于治疗炎症性和自身免疫性疾病。IVIg 引起的皮肤反应通常较轻。汗疱疹是手掌、足底和/或手指侧面出现小水疱的常见皮疹。它的病因是多因素的,但很少归因于药物相关的副作用。我们描述了一位 43 岁女性,她因外周感觉神经病接受 IVIg 治疗后,双手手掌均出现汗疱疹样湿疹。

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1
Eczematous Drug Eruptions.湿疹样药疹。
Am J Clin Dermatol. 2021 May;22(3):349-366. doi: 10.1007/s40257-021-00586-8. Epub 2021 Feb 15.
3
Update on the use of immunoglobulin in human disease: A review of evidence.免疫球蛋白在人类疾病中的应用更新:证据回顾。
J Allergy Clin Immunol. 2017 Mar;139(3S):S1-S46. doi: 10.1016/j.jaci.2016.09.023. Epub 2016 Dec 29.

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