Oral and Maxillofacial Pathology & Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odisha, India.
Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Ansuandhan deemed to be University, Bhubaneswar, India.
BMJ Case Rep. 2022 Mar 30;15(3):e249027. doi: 10.1136/bcr-2022-249027.
Primary amelanotic melanoma is an infrequent occurrence in the oral cavity. Owing to the high rate of local invasion and distant metastasis, oral amelanotic melanoma (OAM) carries a very poor prognosis. The absence of pathognomonic clinical and routine histological features in OAM is the reason for diagnosticdelay, which further worsens the prognosis. This case report discusses the masquerading nature of OAM that was clinically and histologically mimicking several malignant neoplasms. This case also demonstrates the poor prognosis of OAM. The objective of presenting this case is that the diagnostic delay of OAM can be avoided through enhanced clinical awareness and subsequent appropriate immunohistochemical investigations, in addition to the routine H&E-stained histopathological evaluation.
原发性无黑色素性黑色素瘤在口腔中较为罕见。由于其局部侵袭和远处转移的高发生率，口腔无黑色素性黑色素瘤（OAM）的预后非常差。OAM 缺乏特征性的临床和常规组织学特征是导致诊断延误的原因，进一步恶化了预后。本病例报告讨论了 OAM 的伪装性质，其在临床上和组织学上模仿了几种恶性肿瘤。本病例还表明了 OAM 的预后不良。提出这个病例的目的是，通过增强临床意识和随后进行适当的免疫组织化学检查，除了常规的 H&E 染色组织病理学评估外，还可以避免 OAM 的诊断延误。
