严重支气管肺发育不良婴儿与系统性高血压相关的后遗症。
Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia.
机构信息
Monash Newborn, Monash Children's Hospital, Melbourne, Australia.
Department of Paediatrics, Monash University, Melbourne, Australia.
出版信息
J Perinatol. 2022 Jun;42(6):775-780. doi: 10.1038/s41372-022-01372-y. Epub 2022 Mar 30.
OBJECTIVES
To ascertain correlation between systemic hypertension and respiratory sequelae amongst infants with BPD.
STUDY DESIGN
Retrospective evaluation of six-year data compared infants with severe BPD to infants with no BPD. 7-day morning blood pressure (BP) (36-36 week) was compared with 95th centile cut-offs.
RESULTS
57 infants with BPD were compared with 114 infants with no BPD. Gestation and birthweight were comparable (median [interquartile range], (27 [25, 28] vs. 26.5 weeks [25, 28], p = 0.7 and 706 g [611, 884] vs. 730 [630, 895]), p = 0.1. Number of infants having BP ≥ 95th centile was significantly higher in BPD cohort (systolic BP, 23/57 [40.3%] vs. 3/114 [2.6%], p < 0.001 & mean arterial BP, 26/57 [46%] vs. 3/114 [2.6%], p < 0.001). Amongst BPD infants, higher BP was associated with longer duration of respiratory support (median [range], 109 days [81-138] vs. 87 [58-109], p < 0.001).
CONCLUSIONS
Infants with severe BPD had higher BP compared to those without BPD.
目的
确定患有 BPD 的婴儿中系统性高血压与呼吸后遗症之间的相关性。
研究设计
对六年数据进行回顾性评估，将患有严重 BPD 的婴儿与无 BPD 的婴儿进行比较。比较了 7 天早晨血压（BP）（36-36 周）与 95 百分位的截断值。
结果
将 57 名患有 BPD 的婴儿与 114 名无 BPD 的婴儿进行比较。胎龄和出生体重相当（中位数[四分位距]，（27 [25, 28]与 26.5 周[25, 28]，p=0.7 和 706 [611, 884]与 730 [630, 895]，p=0.1）。患有 BP≥95 百分位的婴儿数量在 BPD 组中明显更高（收缩压，23/57 [40.3%]与 3/114 [2.6%]，p<0.001；平均动脉压，26/57 [46%]与 3/114 [2.6%]，p<0.001）。在 BPD 婴儿中，较高的血压与更长的呼吸支持时间相关（中位数[范围]，109 天[81-138]与 87 [58-109]，p<0.001）。
结论
患有严重 BPD 的婴儿的血压高于无 BPD 的婴儿。
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