Alagappan A, Malloy M H
Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0526, USA.
Am J Perinatol. 1998 Jan;15(1):3-8. doi: 10.1055/s-2007-993889.
The purpose of our study was to determine if systemic hypertension (HTN) occurred among infants with birth weight less than 1250 g (very low-birth-weight [VLBW] infants) in association with Bronchopulmonary dysplasia (BPD). We designed a historical cohort study to review the clinical course and the occurrence of systemic HTN in infants born during the year 1992 with birth weights between 600-1250 g. The overall incidence of HTN was 6.8% (5 of 73) and the incidence in infants with BPD was 12% (5 of 41). The mean age of onset of HTN was 105 days (range 90 to 133 days), and at the time of discharge 3 of 5 (60%) infants remained hypertensive and 3 of 5 (60%) were on supplemental oxygen. All the five hypertension infants (100%) were on supplemental oxygen at 36 weeks of postceptional age compared to 18 of 36 (50%) of nonhypertensive BPD infants. The association between HTN and severe BPD was further denoted by longer hospital stay (145 +/- 37 vs. 94 +/- 28 days, p = 0.004), longer duration of O2 therapy (108 +/- 36 vs. 67 +/- 34 days, p = 0.01), and prolonged use of aminophylline (104 +/- 44 vs. 61 +/- 23 days, p = 0.03), in the hypertensive BPD infants versus nonhypertensive BPD infants, respectively. This study substantiates an increased risk of developing systemic HTN, among VLBW infants with severe BPD.
我们研究的目的是确定出生体重低于1250克的婴儿（极低出生体重[VLBW]婴儿）中是否会出现与支气管肺发育不良（BPD）相关的系统性高血压（HTN）。我们设计了一项历史性队列研究，以回顾1992年出生、体重在600 - 1250克之间的婴儿的临床病程及系统性HTN的发生情况。HTN的总体发生率为6.8%（73例中有5例），BPD婴儿中的发生率为12%（41例中有5例）。HTN的平均发病年龄为105天（范围90至133天），出院时5例中有3例（60%）婴儿仍患有高血压，5例中有3例（60%）仍在吸氧。与36例非高血压BPD婴儿中的18例（50%）相比，所有5例高血压婴儿（100%）在孕龄36周时都在吸氧。HTN与严重BPD之间的关联还表现为，高血压BPD婴儿与非高血压BPD婴儿相比，住院时间更长（145±37天对94±28天，p = 0.004），吸氧治疗时间更长（108±36天对67±34天，p = 0.01），氨茶碱使用时间延长（104±44天对61±23天，p = 0.03）。这项研究证实，患有严重BPD的极低出生体重婴儿发生系统性HTN的风险增加。
