Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Trans R Soc Trop Med Hyg. 2022 Oct 2;116(10):944-948. doi: 10.1093/trstmh/trac018.
Kyasanur Forest disease (KFD) is a viral zoonotic disease where patients present with febrile illness and haemorrhagic manifestations in the first phase. In a small fraction of patients, the fever may be biphasic. This study aimed to describe the neurological manifestations of patients with KFD in the first and second phases of the illness.
This is a retrospective cohort study of 297 patients admitted with a molecular diagnosis of KFD from December 2018 to December 2020. The case records of these patients were reviewed for evidence of neurological involvement.
A total of 34 (11.5%) patients in the first phase and 16 (36.4%) patients in the second phase had neurological involvement. Altered sensorium, seizures and focal infarcts were common in the first phase, while cerebellar signs and leptomeningeal enhancement were common in the second phase.
Neurological involvement is seen in both phases of KFD. While in the first phase it is a result of possible encephalitis/encephalopathy, the second phase involvement is possibly due to postinfectious cerebellitis or meningitis.
基孔肯雅热（KFD）是一种病毒性人畜共患疾病，患者在第一阶段表现为发热和出血表现。在一小部分患者中，发热可能呈双峰热型。本研究旨在描述 KFD 患者在疾病的第一和第二阶段的神经表现。
这是一项回顾性队列研究，纳入了 2018 年 12 月至 2020 年 12 月期间因分子诊断为 KFD 而住院的 297 例患者。对这些患者的病例记录进行了审查，以寻找神经受累的证据。
在第一阶段，共有 34 例（11.5%）患者，在第二阶段，有 16 例（36.4%）患者出现神经受累。意识改变、癫痫发作和局灶性梗死在第一阶段很常见，而在第二阶段，小脑体征和软脑膜强化很常见。
KFD 的两个阶段均可见神经受累。第一阶段的受累可能是脑炎/脑病所致，而第二阶段的受累可能是感染后小脑炎或脑膜炎所致。
