JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA, 52317, USA.
Eur J Clin Microbiol Infect Dis. 2022 May;41(5):867-873. doi: 10.1007/s10096-022-04437-0. Epub 2022 Mar 30.
Dalbavancin and comparators were susceptibility tested against 8643 Gram-positive bacteria from 74 hospitals located in Europe and the United States by broth microdilution method. The most common organisms were Staphylococcus aureus (45.2%), Enterococcus faecalis (12.2%), and Staphylococcus epidermidis (8.9%), but rank order varied markedly by geographic region. Dalbavancin demonstrated potent activity and broad spectrum, with MIC values of 0.03 mg/L for Staphylococcus aureus, β-haemolytic streptococci, and viridans group streptococci; 0.06 mg/L for Enterococcus faecalis and Staphylococcus epidermidis; and 0.12 mg/L for vancomycin-susceptible Enterococcus faecium. All organisms, except vancomycin-resistant enterococci and 1 Staphylococcus haemolyticus isolate, were inhibited at ≤ 0.25 mg/L of dalbavancin.
达巴万星和对照药物采用肉汤微量稀释法对来自欧洲和美国 74 家医院的 8643 株革兰阳性菌进行了药敏试验。最常见的病原体为金黄色葡萄球菌（45.2%）、粪肠球菌（12.2%）和表皮葡萄球菌（8.9%），但不同地区的优势菌种存在显著差异。达巴万星具有强大的抗菌活性和广谱抗菌谱，对金黄色葡萄球菌、β-溶血性链球菌和草绿色链球菌的 MIC 值为 0.03mg/L；对粪肠球菌和表皮葡萄球菌的 MIC 值为 0.06mg/L；对万古霉素敏感的屎肠球菌的 MIC 值为 0.12mg/L。除了万古霉素耐药肠球菌和 1 株溶血性葡萄球菌分离株外，所有受试菌的 MIC 值均≤0.25mg/L 时，均可被达巴万星抑制。
