Mellman T A, Uhde T W
Am J Psychiatry. 1986 Nov;143(11):1464-6. doi: 10.1176/ajp.143.11.1464.
The clinical and biological correlates of gradual alprazolam withdrawal were investigated in 10 patients in a double-blind, placebo-controlled trial. During gradual alprazolam withdrawal, anxiety and plasma cortisol levels were higher than during a postwithdrawal medication-free period.
在一项双盲、安慰剂对照试验中,对10名患者逐渐停用阿普唑仑的临床和生物学相关性进行了研究。在逐渐停用阿普唑仑期间,焦虑和血浆皮质醇水平高于停药后无药物治疗期。